ArticlePLoS genetics2018
Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- miR-210 is essential to retinal homeostasis in fruit flies and mice.Biology direct · 2024Article
- NF-κB factors cooperate with Su(Hw)/E4F1 to balance Drosophila/human immune responses via modulating dynamic expression of miR-210.Nucleic acids research · 2024Article
- miR-277 regulates the phase of circadian activity-rest rhythm inFrontiers in physiology · 2023Article
- Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.Hereditas · 2022Article
- Photoperiod-Dependent Expression of MicroRNA inInternational journal of molecular sciences · 2022Article
- Abundant small RNAs in the reproductive tissues and eggs of the honey bee, Apis mellifera.BMC genomics · 2022Article
- The developmentally dynamic microRNA transcriptome ofBioinformatics advances · 2022Article
- The Role of microRNAs in theFrontiers in cell and developmental biology · 2022Review
- Post-transcriptional modulators and mediators of the circadian clock.Chronobiology international · 2021Review
- MicroRNA-210 Regulates Dendritic Morphology and Behavioural Flexibility in Mice.Molecular neurobiology · 2021Article
- The conserved microRNA miR-210 regulates lipid metabolism and photoreceptor maintenance in the Drosophila retina.Cell death and differentiation · 2021Article
- Mesencephalic Astrocyte-Derived Neurotrophic Factor Regulates Morphology of Pigment-Dispersing Factor-Positive Clock Neurons and Circadian Neuronal Plasticity inFrontiers in physiology · 2021Article
- Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation.African health sciences · 2020Article
- Regulation of circadian rhythm and sleep by miR-375-timeless interaction in Drosophila.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment.Current biology : CB · 2020Article
- Better Sleep at Night: How Light Influences Sleep inFrontiers in physiology · 2020Review
- miR-210 controls the evening phase of circadian locomotor rhythms through repression of Fasciclin 2.PLoS genetics · 2019Article
- Different mechanisms for selective transport of fatty acids using a single class of lipoprotein inJournal of lipid research · 2019Article
- Loss of miR-210 leads to progressive retinal degeneration inLife science alliance · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Single microRNAs are usually associated with hundreds of putative target genes that can influence multiple phenotypic traits in Drosophila, ranging from development to behaviour. We investigated the function of Drosophila miR-210 in circadian behaviour by misexpressing it within circadian clock cells. Manipulation of miR-210 expression levels in the PDF (pigment dispersing factor) positive neurons affected the phase of locomotor activity, under both light-dark conditions and constant darkness. PER cyclical expression was not affected in clock neurons, however, when miR-210 was up-regulated, a dramatic alteration in the morphology of PDF ventral lateral neuron (LNv) arborisations was observed. The effect of miR-210 in shaping neuronal projections was confirmed in vitro, using a Drosophila neuronal cell line. A transcriptomic analysis revealed that miR-210 overexpression affects the expression of several genes belonging to pathways related to circadian processes, neuronal development, GTPases signal transduction and photoreception. Collectively, these data reveal the role of miR-210 in modulating circadian outputs in flies and guiding/remodelling PDF positive LNv arborisations and indicate that miR-210 may have pleiotropic effects on the clock, light perception and neuronal development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.