ArticleMolecular plant pathology2018
Massive up-regulation of LBD transcription factors and EXPANSINs highlights the regulatory programs of rhizomania disease.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 39 citations in OpenAlex.
- Structures of Nicotiana benthamiana importin-α1 complexes reveal mechanisms for plant virus NLS recognition.The Plant journal : for cell and molecular biology · 2026Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- Natural genetic variation of a single amino acid in beet necrotic yellow vein virus P31 protein modulates evasion of plant ubiquitination-mediated antiviral immunity.PLoS pathogens · 2026Article
- GATA8-Mediated Antiviral Defence Is Countered by Tomato Chlorosis Virus-Encoded Pathogenicity Protein p27.Molecular plant pathology · 2025Article
- A Study on the Functional Identification of Overexpressing Winter Wheat Expansin GeneInternational journal of molecular sciences · 2024Article
- Article
- Investigation of the expansin gene family in sugar beet (Beta vulgaris) by the genome-wide level and their expression responses under abiotic stresses.Biologia futura · 2023Article
- ZmLBD2 a maize (Frontiers in plant science · 2022Article
- Manipulation of auxin signalling by plant viruses.Molecular plant pathology · 2021Review
- The Virulence Factor p25 of Beet Necrotic Yellow Vein Virus Interacts With Multiple Aux/IAA Proteins FromFrontiers in microbiology · 2021Article
- Alternative splicing profiling provides insights into the molecular mechanisms of peanut peg development.BMC plant biology · 2020Article
- Complex Molecular Evolution and Expression of Expansin Gene Families in Three Basic Diploid Species ofInternational journal of molecular sciences · 2020Article
- Phylogeny and Functions of LOB Domain Proteins in Plants.International journal of molecular sciences · 2020Review
- Phenotypic and Transcriptomic Analysis of Two Pinellia ternata Varieties T2 line and T2Plus line.Scientific reports · 2020Article
- Comparative Transcriptome Analysis Provides Molecular Insights into the Interaction ofViruses · 2020Article
- Application of a Reverse Genetic System forFrontiers in plant science · 2019Article
- Lateral Root Primordium Morphogenesis in Angiosperms.Frontiers in plant science · 2019Review
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Authors and funding
9 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Rhizomania of sugar beet, caused by Beet necrotic yellow vein virus (BNYVV), is characterized by excessive lateral root (LR) formation leading to dramatic reduction of taproot weight and massive yield losses. LR formation represents a developmental process tightly controlled by auxin signaling through AUX/IAA-ARF responsive module and LATERAL ORGAN BOUNDARIES DOMAIN (LBD) transcriptional network. Several LBD transcription factors play central roles in auxin-regulated LR development and act upstream of EXPANSINS (EXPs), cell wall (CW)-loosening proteins involved in plant development via disruption of the extracellular matrix for CW relaxation and expansion. Here, we present evidence that BNYVV hijacks these auxin-regulated pathways resulting in formation LR and root hairs (RH). We identified an AUX/IAA protein (BvAUX28) as interacting with P25, a viral virulence factor. Mutational analysis indicated that P25 interacts with domains I and II of BvAUX28. Subcellular localization of co-expressed P25 and BvAUX28 showed that P25 inhibits BvAUX28 nuclear localization. Moreover, root-specific LBDs and EXPs were greatly upregulated during rhizomania development. Based on these data, we present a model in which BNYVV P25 protein mimics action of auxin by removing BvAUX28 transcriptional repressor, leading to activation of LBDs and EXPs. Thus, the evidence highlights two pathways operating in parallel and leading to uncontrolled formation of LRs and RHs, the main manifestation of the rhizomania syndrome.
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