ReviewMolecular plant pathology2018
Molecular mechanisms that limit the costs of NLR-mediated resistance in plants.
Review in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- No Cost of Resistance in Wheat Gene Stack Lines Containing 10 Stem Rust Resistance Transgenes.Plant biotechnology journal · 2026Article
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Polyploidy and plant resilience to environmental stresses: Molecular mechanisms and future applications.Plant communications · 2026Review
- Grasping Molecular Biology Mechanisms to Optimize Plant Resistance and Advance Microbiome Role Against Phytonematodes.International journal of molecular sciences · 2026Review
- Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- A well-annotated genome of Apium graveolens var. dulce cv. Challenger, a celery with resistance to Fusarium oxysporum f. sp. apii race 2.The Plant journal : for cell and molecular biology · 2025Article
- Tracing the path from conservation to expansion evolutionary insights into NLR genes in oleaceae.BMC plant biology · 2025Article
- Arabidopsis MORC1 and MED9 Interact to Regulate Defense Gene Expression and Plant Fitness.The plant pathology journal · 2024Article
- Comparative analysis, diversification, and functional validation of plant nucleotide-binding site domain genes.Scientific reports · 2024Article
- Wheat Pm55 alleles exhibit distinct interactions with an inhibitor to cause different powdery mildew resistance.Nature communications · 2024Article
- The Hypersensitive Response to Plant Viruses.Viruses · 2023Review
- Simultaneous mutations inPlant signaling & behavior · 2022Article
- Engineering Resistance againstPlants (Basel, Switzerland) · 2022Article
- Characterization of defense responses against bacterial pathogens in duckweeds lacking EDS1.The New phytologist · 2022Article
- Genome-Wide Transcriptomic Analysis of the Effects of Infection with the Hemibiotrophic FungusPlants (Basel, Switzerland) · 2022Article
- Plant autoimmunity-fresh insights into an old phenomenon.Plant physiology · 2022Article
- Article
- Multilevel evolution shapes the function of NB-LRR encoding genes in plant innate immunity.Frontiers in plant science · 2022Review
- The INCREASE project: Intelligent Collections of food-legume genetic resources for European agrofood systems.The Plant journal : for cell and molecular biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crop diseases cause significant yield losses, and the use of resistant cultivars can effectively mitigate these losses and control many plant diseases. Most plant resistance (R) genes encode immune receptors composed of nucleotide-binding and leucine-rich repeat (NLR) domains. These proteins mediate the specific recognition of pathogen avirulence effectors to induce defence responses. However, NLR-triggered immunity can be associated with a reduction in growth and yield, so-called 'fitness costs'. Recent data have shown that plants use an elaborate interplay of different mechanisms to control NLR gene transcript levels, as well as NLR protein abundance and activity, to avoid the associated cost of resistance in the absence of a pathogen. In this review, we discuss the different levels of NLR regulation (transcriptional, post-transcriptional and at the protein level). We address the apparent need for plants to maintain diverse modes of regulation. A recent model suggesting an equilibrium 'ON/OFF state' of NLR proteins, in the absence of a pathogen, provides the context for our discussion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.