SynthesisJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2018
Measures of Physical Performance and Muscle Strength as Predictors of Fracture Risk Independent of FRAX, Falls, and aBMD: A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study.
Synthesis in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Recent sarcopenia definitions-prevalence, agreement and mortality associations among men: Findings from population-based cohorts.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAXJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Pooled it
- Pooled it
- Effects of resistance exercise in prostate cancer patients : A systematic review update as of March 2020.Wiener klinische Wochenschrift · 2020Pooled it
- The Analysis for Anemia Increasing Fracture Risk.Medical science monitor : international medical journal of experimental and clinical research · 2020Pooled it
- Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial.Nature communications · 2024Trial
- Effects of Adding an Online Exercise Program on Physical Function in Individuals Hospitalized by COVID-19: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Objective Physical Performance Predicts 10-Year Fracture Risk Without Densitometry in Older Men and Women: Development and Head-to-Head Comparison with FRAX in MrOS and SOF.Calcified tissue international · 2026Article
- Distinct Cortical Microstructure in Postmenopausal Women with Distal Radius and Proximal Humerus Fractures.Calcified tissue international · 2026Article
- The SINTER study: a recall-by-genotype design with multidimensional musculoskeletal phenotyping across internal-medicine outpatient clinics.European journal of epidemiology · 2026Article
- HR-pQCT skeletal phenotype clustering associated with muscle function in older men and women: The Study of Muscle, Mobility and Aging (SOMMA).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Sarcopenia and fall-related outcomes in Chinese adults aged 45 years or older: a longitudinal cohort study.Scientific reports · 2026Article
- Article
- Fracture Occurrence Within FRAX-Defined High-Risk Myasthenia Gravis: An Exploratory Stratification by Age and Activities of Daily Living.Journal of clinical medicine · 2026Article
- Is trabecular bone score associated with appendicular lean mass?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Recent Sarcopenia Definitions-Variability in Prevalence and Disability Associations in Peritoneal Dialysis Patients.Journal of cachexia, sarcopenia and muscle · 2025Article
- Development and performance verification of an isometric dynamometer for lower extremity.Scientific reports · 2025Article
- Sex-specific associations of fat and lean indices with vertebral fractures.Scientific reports · 2025Article
- Prediction of 10-Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort.Journal of cachexia, sarcopenia and muscle · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 11 institutions in 7 countries.
Funding
Abstract
Measures of muscle mass, strength, and function predict risk of incident fractures, but it is not known whether this risk information is additive to that from FRAX (fracture risk assessment tool) probability. In the Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, Hong Kong, United States), we investigated whether measures of physical performance/appendicular lean mass (ALM) by DXA predicted incident fractures in older men, independently of FRAX probability. Baseline information included falls history, clinical risk factors for falls and fractures, femoral neck aBMD, and calculated FRAX probabilities. An extension of Poisson regression was used to investigate the relationship between time for five chair stands, walking speed over a 6 m distance, grip strength, ALM adjusted for body size (ALM/height
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.