Evidence map›Paper›PMID 30011084›Full record

ArticleJournal of cellular biochemistry2018

The proto-oncogene function of Mdm2 in bone.

David J Olivos, Daniel S Perrien, Adam Hooker, Ying-Hua Cheng, Robyn K Fuchs, Jung Min Hong, Angela Bruzzaniti, Kristin Chun, Christine M Eischen, Melissa A Kacena and 1 more

Abstract read
In one paragraph

Article in Journal of cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

David J OlivosDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana.
Daniel S PerrienDepartments of Medicine and Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, and Tennessee Valley Healthcare System, Nashville, Tennessee.
Adam HookerDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Ying-Hua ChengDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Robyn K FuchsDepartment of Physical Therapy, Indiana University School of Health and Rehabilitation Sciences, Indianapolis, Indiana.
Jung Min HongDepartment of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana.
Angela BruzzanitiDepartment of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana.
Kristin ChunDepartment of Pediatrics, Herman B Wells Center for Pediatrics Research, Indiana University School of Medicine, Indianapolis, Indiana.
Christine M EischenDepartment of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Melissa A KacenaDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Lindsey D MayoDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0002-5997-5166
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USIndiana University Health · USThomas Jefferson University · USVA Tennessee Valley Healthcare System · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
REGULATION OF HEMATOPOIETIC CELL PRODUCTIONT32DK007519 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 1986 to 2020
$7.1M
Regulating hematopoietic stem cells and hematopoiesis for clinical efficacyP30DK090948 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., SROUR, EDWARD F · 2010 to 2014
$3.7M
Indiana Clinical and Translational Sciences InstituteTL1TR001107 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$2.0M
Regulation of Mdm2 activity by kinase signaling pathwaysR01CA172256 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI MAYO, LINDSEY D · 2013 to 2017
$1.8M
Regulation of Osteoblast Function by Megakaryocytes: Key Signaling ProteinsR01AR060332 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRUZZANITI, ANGELA, KACENA, MELISSA A · 2011 to 2015
$1.7M
Thrombopoietin: A novel regulator of bone healingR01AR060863 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI KACENA, MELISSA A · 2012 to 2016
$1.7M
Novel oncogenic functions of Mdm2 and MdmxR01CA181204 · NCI · VANDERBILT UNIVERSITY · PI EISCHEN, CHRISTINE M. · 2014 to 2018
$1.6M
NCATS NIH HHS TL1 TR001107NCATS NIH HHS UL1 TR001108NCI NIH HHS P30 CA082709NCI NIH HHS R01 CA172256NCI NIH HHS R01 CA181204NIAMS NIH HHS R01 AR060332NIAMS NIH HHS R01 AR060863NIDDK NIH HHS P30 DK090948NIDDK NIH HHS T32 DK007519
6 · The paper itself

Abstract

Mouse double minute 2 (Mdm2) is a multifaceted oncoprotein that is highly regulated with distinct domains capable of cellular transformation. Loss of Mdm2 is embryonically lethal, making it difficult to study in a mouse model without additional genetic alterations. Global overexpression through increased Mdm2 gene copy number (Mdm2

Indexed as

Analysis of VarianceAnimalsBone DensityBone RemodelingCalcification, PhysiologicCancellous BoneCell Line, TumorFemaleHumansMaleMiceMice, Inbred C57BLMice, Inbred DBAOsteoblastsOsteoclastsOsteogenesisMAS1 protein, humanMDM2 protein, humanMdm2 protein, mouseProto-Oncogene MasProto-Oncogene Proteins c-mdm2bone massmouse double minute 2 (Mdm2)osteoblast (OB)

Identifiers

PMID30011084
PMCPMC6348883
OpenAlexW2883910787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.