ReviewAnnals of the New York Academy of Sciences2018
Early life adversity and health-risk behaviors: proposed psychological and neural mechanisms.
Review in Annals of the New York Academy of Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06119503 (Peer Delivered Episodic Future Thinking to Improve MOUD Treatment Engagement Among Returning Citizens - A Randomized Controlled Trial), which is not on this map. Cited by 141 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peer Delivered Episodic Future Thinking to Improve MOUD Treatment Engagement Among Returning Citizens - A Randomized Controlled Trial
Who cites it
141 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Impact of parental adverse childhood experiences on children's healthcare utilisation: a systematic review.Journal of epidemiology and community health · 2026Pooled it
- Meta-analysis of Early Risk Factors Associated with Cerebrovascular Diseases.Current neurovascular research · 2026Pooled it
- Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Pooled it
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- Measuring adversity in the ABCD® Study: systematic review and recommendations for best practices.BMC medical research methodology · 2025Pooled it
- Adverse childhood events and mental health problems in cancer survivors: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Emotion-related impulsivity and risky decision-making: A systematic review and meta-regression.Clinical psychology review · 2023Pooled it
- Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Mindfulness-Based Mobile Health to Address Unhealthy Eating Among Middle-Aged Sexual Minority Women With Early Life Adversity: Mixed Methods Feasibility Trial.Journal of medical Internet research · 2023Trial
- Sex-dependent associations of low birth weight and suicidal ideation in adulthood: a community-based cohort study.Scientific reports · 2020Trial
- Long-term impact of childhood exposure to interparental physical violence on cancer risk in adulthood: a prospective cohort study.European journal of psychotraumatology · 2026Article
- The Revised ACE Pyramid: A Contemporary Framework for Understanding Childhood Adversity and Advancing Toxic Stress Prevention and Healing.Children (Basel, Switzerland) · 2026Article
- Emotional Support Moderates Early Life Adversity's Impact on High Molecular Weight Adiponectin in Adolescent Females.Journal of child & adolescent trauma · 2026Article
- Exploring the mediating role of functional connectivity in the association between violence exposure and psychopathology during early adolescence.Brain and cognition · 2026Article
- Early life adversity and cardiometabolic risk in adolescents: Comparison of dimensional and cumulative approaches to adversity.Social science & medicine (1982) · 2026Article
- The associations of childhood and adolescence psychosocial risks with social relations in midlife.Scientific reports · 2026Article
- Cognitive and affective neurodevelopment in youth exposed to deprivation and threat.bioRxiv : the preprint server for biology · 2026Article
- Parental violent discipline and adolescent health: is there a different effect when one or both parents are involved?European journal of public health · 2026Article
- Threat, Emotion Dysregulation, and Parenting in a Clinical Sample of Children with Disruptive Behaviour.Child psychiatry and human development · 2026Article
- Childhood trauma and impulsive behaviors: the multiple chain mediating effects of neuroticism, stress perception and depression.BMC psychology · 2026Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Early life adversity (ELA) is associated with poorer health in adulthood, an association explained, at least in part, by increased engagement in health-risk behaviors (HRBs). In this review, we make the case that ELA influences brain development in ways that increase the likelihood of engaging in HRBs. We argue that ELA alters neural circuitry underpinning cognitive control as well as emotional processing, including networks involved in processing threat and reward. These neural changes are associated psychologically and behaviorally with heightened emotional reactivity, blunted reward responsivity, poorer emotion regulation, and greater delay discounting. We then demonstrate that these adaptations to ELA are associated with an increased risk of smoking cigarettes, drinking alcohol, and eating high-fat, high-sugar foods. Furthermore, we explore how HRBs affect the brain in ways that reinforce addiction and further explain clustering of HRBs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.