ReviewIntegrative and comparative biology2018
Life History Trade-offs within the Context of Mitochondrial Hormesis.
Review in Integrative and comparative biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Paracetamol Responses Depend on Temperature, Life Stage, and Genetic Background inMedicines (Basel, Switzerland) · 2026Article
- Effects of storage conditions on oxidative stress biomarkers: methodological implications for ecological and evolutionary studies.The Journal of experimental biology · 2026Article
- Wild-Derived House Mice (Mus musculus) Are Able to Cope With a Constant Light Environment.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- The cell origin of reactive oxygen species and its implication for evolutionary trade-offs.Open biology · 2025Review
- Oxidative Stress in an African Ground Squirrel, a Case of Healthy Aging and Reproduction.Antioxidants (Basel, Switzerland) · 2024Article
- Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes.GeroScience · 2024Article
- Filial cannibalism influences the link between gonadal development and antioxidant function in a mouthbrooding cichlid fish.microPublication biology · 2024Article
- Metabolic stress as a driver of life-history plasticity: flight promotes longevity and antioxidant production in monarch butterflies.Proceedings. Biological sciences · 2023Article
- The Evolution and Ecology of Oxidative and Antioxidant Status: A Comparative Approach in African Mole-Rats.Antioxidants (Basel, Switzerland) · 2023Article
- The Genetics of Fitness Reorganization during the Transition to Multicellularity: The VolvocineGenes · 2023Review
- Tissue Oxidative Ecology along an Aridity Gradient in a Mammalian Subterranean Species.Antioxidants (Basel, Switzerland) · 2022Article
- Copepod reproductive effort and oxidative status as responses to warming in the marine environment.Ecology and evolution · 2022Article
- A life-history trade-off gene with antagonistic pleiotropic effects on reproduction and survival in limiting environments.Proceedings. Biological sciences · 2022Article
- Mitonuclear interactions alter sex-specific longevity in a species without sex chromosomes.Proceedings. Biological sciences · 2021Article
- The Type and Source of Reactive Oxygen Species Influences the Outcome of Oxidative Stress in Cultured Cells.Cells · 2021Article
- Effects of Heat Waves During Post-natal Development on Mitochondrial and Whole Body Physiology: An Experimental Study in Zebra Finches.Frontiers in physiology · 2021Article
- Healthful aging mediated by inhibition of oxidative stress.Ageing research reviews · 2020Review
- Mitochondrial pathways in human health and aging.Mitochondrion · 2020Review
- Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Differential expression of antioxidant system genes in honey bee (Apis mellifera L.) caste development mitigates ROS-mediated oxidative damage in queen larvae.Genetics and molecular biology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Evolutionary biologists have been interested in the negative interactions among life history traits for nearly a century, but the mechanisms that would create this negative interaction remain poorly understood. One variable that has emerged as a likely link between reproductive effort and longevity is oxidative stress. Specifically, it has been proposed that reproduction generates free radicals that cause oxidative stress and, in turn, oxidative stress damages cellular components and accelerates senescence. We propose that there is limited support for the hypothesis because reactive oxygen species (ROS), the free radicals implicated in oxidative damage, are not consistently harmful. With this review, we define the hormetic response of mitochondria to ROS, termed mitochondrial hormesis, and describe how to test for a mitohormetic response. We interpret existing data using our model and propose that experimental manipulations will further improve our knowledge of this response. Finally, we postulate how the mitohormetic response curve applies to variation in animal performance and longevity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.