ArticleNucleic acids research2018
Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis with control of DNA nanoflowers towards biomedical applications.Materials today. Bio · 2025Review
- Sonodynamic Therapy-Based DNA Nanocarriers with Hypoxia-Inducible Factor-1α Silencing Activation for Precision Lung Cancer Therapy.Biomaterials research · 2025Article
- Transforming cancer detection and treatment with nanoflowers.Medical oncology (Northwood, London, England) · 2024Review
- Bimodal DNA self-origami material with nucleic acid function enhancement.Journal of nanobiotechnology · 2024Article
- Hierarchical self-uncloaking CRISPR-Cas13a-customized RNA nanococoons for spatial-controlled genome editing and precise cancer therapy.Science advances · 2022Article
- Single-stranded circular DNA theranostics.Theranostics · 2022Review
- Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification.Nucleic acids research · 2021Article
- Article
- Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications.Nanotechnology, science and applications · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently reported DNA nanoflowers are an interesting class of organic-inorganic hybrid materials which are prepared using DNA polymerases. DNA nanoflowers combine the high surface area and scaffolding of inorganic Mg2P2O7 nanocrystals with the targeting properties of DNA, whilst adding enzymatic stability and enhanced cellular uptake. We have investigated conditions for chemically modifying the inorganic core of these nanoflowers through substitution of Mg2+ with Mn2+, Co2+ or Zn2+ and have characterized the resulting particles. These have a range of novel nanoarchitectures, retain the enzymatic stability of their magnesium counterparts and the Co2+ and Mn2+ DNA nanoflowers have added magnetic properties. We investigate conditions to control different morphologies, DNA content, hybridization properties, and size. Additionally, we show that DNA nanoflower production is not limited to Ф29 DNA polymerase and that the choice of polymerase can influence the DNA length within the constructs. We anticipate that the added control of structure, size and chemistry will enhance future applications.
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Registered trials
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