ReviewEndocrinology2018
Age and Sex Are Critical Factors in Ischemic Stroke Pathology.
Review in Endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
234 citing papers in PubMed, 7 syntheses or guidelines pooled it, 462 citations in OpenAlex.
- The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.Brain and behavior · 2025Pooled it
- A Meta-Analysis of the Relationship between Stroke and Alzheimer's Disease: Therapeutic and Prognostic Implications.Kidney & blood pressure research · 2025Pooled it
- Risk prediction models for short-term mortality in ICU stroke patients: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Machine learning prediction of motor function in chronic stroke patients: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Efficacy of meridian massage for motor function after a stroke: a systematic review and Meta-analysis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Pooled it
- Ischemic stroke associated with COVID-19: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Neuroprotection by Remote Ischemic Conditioning in Rodent Models of Focal Ischemia: a Systematic Review and Meta-Analysis.Translational stroke research · 2021Pooled it
- Effects of structured positive feedback intervention on standing reach ability among older adults admitted to a convalescent rehabilitation ward: a small-sample pilot randomized controlled trial.European geriatric medicine · 2025Trial
- A prediction model for functional outcome following rescue therapy in patients with acute ischemic stroke undergoing endovascular treatment.Annals of medicine · 2026Article
- Observational
- Research progress of traditional Chinese medicine interventions for aging-related nervous system diseases.Biogerontology · 2026Review
- Factors associated with symptom relief and lesion formation in acute ischemic stroke and transient ischemic attack.BMC neurology · 2026Article
- Prognostic Factors in Acute Ischemic Stroke With a Decreased Estimated Glomerular Filtration Rate.Brain and behavior · 2026Article
- Sex Differences in the Protective Effect of Brain Volume: Age Attenuates Protection in Women.Stroke (Hoboken, N.J.) · 2026Article
- Awareness and perception of the traditional methods of stroke management among stroke survivors in selected health facilities and traditional centers: a mixed method study.BMC complementary medicine and therapies · 2026Article
- Molecular heterogeneity in human stroke - What can we learn from the peripheral blood transcriptome?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Proteomic Analysis of Differentially Expressed Proteins in Ischemic Stroke Recovery and Their Implications for Therapeutic Outcomes.Translational stroke research · 2026Article
- Enhanced Therapeutic Effects of Extracellular Vesicles Targeting MiR-137 Contribute to Functional Recovery by Attenuating Neuronal Injury After Ischemic Stroke.Neuroscience bulletin · 2026Article
- An Epigenetic Switch for Sex-Specific Brain Resilience in Stroke: Targeting HDAC2 to Amplify Endogenous Oxytocin Signaling.ACS central science · 2026Article
- How covariate control can bias our insights into brain architecture and pathology.Scientific reports · 2026Article
174 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ischemic stroke is a devastating brain injury resulting in high mortality and substantial loss of function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional loss is critical to the development of new therapies. Age and sex have a complex and interactive effect on ischemic stroke risk and pathophysiology. Aging is the strongest nonmodifiable risk factor for ischemic stroke, and aged stroke patients have higher mortality and morbidity and poorer functional recovery than their young counterparts. Importantly, patient age modifies the influence of patient sex in ischemic stroke. Early in life, the burden of ischemic stroke is higher in men, but stroke becomes more common and debilitating for women in elderly populations. The profound effects of sex and age on clinical ischemic stroke are mirrored in the results of experimental in vivo and in vitro studies. Here, we review current knowledge on the influence of age and sex in the incidence, mortality, and functional outcome of ischemic stroke in clinical populations. We also discuss the experimental evidence for sex and age differences in stroke pathophysiology and how a better understanding of these biological variables can improve clinical care and enhance development of novel therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.