ArticleIEEE transactions on bio-medical engineering2019
Ionic Direct Current Modulation for Combined Inhibition/Excitation of the Vestibular System.
Article in IEEE transactions on bio-medical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
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- Review
- Galvanic vs. pulsatile effects on decision-making networks: reshaping the neural activation landscape.Journal of neural engineering · 2024Article
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- Ionic transistor using ion exchange membranes.Lab on a chip · 2022Article
- Difference in Network Effects of Pulsatile and Galvanic Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022Article
- IGST Combined with Conventional Drug Therapy and TCM Therapy for Treatment of Bilateral Vestibular Hypofunction.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- A Hydrogel-Based Microfluidic Nerve Cuff for Neuromodulation of Peripheral Nerves.Micromachines · 2021Article
- On-chip ionic current sensor.Applied physics. A, Materials science & processing · 2021Article
- Article
- Clinical Potential of Nerve Input to Tumors: A Bioelectricity Perspective.Bioelectricity · 2021Article
- A microfluidic system integrated with shape memory alloy valves for a safe direct current delivery system.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
- Ionic direct current modulation evokes spike-rate adaptation in the vestibular periphery.Scientific reports · 2019Article
- Implantable Direct Current Neural Modulation: Theory, Feasibility, and Efficacy.Frontiers in neuroscience · 2019Review
- Combined ionic direct current and pulse frequency modulation improves the dynamic range of vestibular canal stimulation.Journal of vestibular research : equilibrium & orientation · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
objectiveProsthetic electrical stimulation delivered to the vestibular nerve could provide therapy for people suffering from bilateral vestibular dysfunction. Common encoding methods use pulse-frequency modulation (PFM) to stimulate the semicircular canals of the vestibular system. We previously showed that delivery of ionic direct current (iDC) can also modulate the vestibular system. In this study, we compare the dynamic range of head velocity encoding from iDC modulation to that of PFM controls.
methodsGentamicin-treated wild-type chinchillas were implanted with microcatheter tubes that delivered ionic current to the left ear vestibular canals and stimulated with steps of anodic/cathodic iDC or PFM. Evoked vestibulo-ocular reflex eye velocity was used to compare PFM and iDC vestibular modulation.
resultsCathodic iDC steps effectively elicited eye rotations consistent with an increased firing rate of the implanted semicircular canal afferents. Anodic iDC current steps elicited eye rotations in the opposite direction that, when paired with an adapted cathodic offset, increased the dynamic range of eye rotation velocities in comparison to PFM controls.
conclusionOur results suggest that iDC modulation can effectively modulate the vestibular system across a functional range of rotation vectors and velocities, with a potential benefit over a PFM stimulation paradigm. SIGNIFICANCE: In conjunction with a safe dc delivery system, iDC modulation could potentially increase the range of simulated head rotation velocities available to neuroelectric vestibular prostheses.
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