Evidence map›Paper›PMID 30010494›Full record

ArticleProsthetics and orthotics international2019

Effects of activity intensity, time, and intermittent doffing on daily limb fluid volume change in people with transtibial amputation.

Robert Tyler Youngblood, Brian J Hafner, Katheryn J Allyn, John C Cagle, Paul Hinrichs, Christian Redd, Andrew C Vamos, Marcia A Ciol, Nate Bean, Joan E Sanders

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Prosthetics and orthotics international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04494555 (Do Adaptable Sockets Improve Military Performance?), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04494555 nacompletednot on this mapstarted 2020, after this paper: background citation

Do Adaptable Sockets Improve Military Performance?

TypeinterventionalSponsorBrooke Army Medical CenterRan2020 to 2024Enrolled15ConditionsAmputation StumpArmsStatic socket, User adjusted socket, Microprocessor-adjusting sockets
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Methods to assess lower limb prosthetic adaptation: a systematic review.Journal of neuroengineering and rehabilitation · 2025
    Pooled it
  2. Article
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  5. A biofidelic mock residual limb for prosthetic socket testing.Canadian prosthetics & orthotics journal · 2025
    Article
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  17. Beyond step counts: Including wear time in prosthesis use assessment for lower-limb amputation.Journal of rehabilitation and assistive technologies engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Robert Tyler YoungbloodUniversity of Washington, Seattle, WA, USA.
Brian J HafnerUniversity of Washington, Seattle, WA, USA.
Katheryn J AllynUniversity of Washington, Seattle, WA, USA.
John C CagleUniversity of Washington, Seattle, WA, USA.
Paul HinrichsUniversity of Washington, Seattle, WA, USA.
Christian ReddUniversity of Washington, Seattle, WA, USA.
Andrew C VamosUniversity of Washington, Seattle, WA, USA.
Marcia A CiolUniversity of Washington, Seattle, WA, USA.
Nate BeanUniversity of Washington, Seattle, WA, USA.
Joan E SandersUniversity of Washington, Seattle, WA, USA.
University of Washington · US

Funding

Measuring In-Socket Residual Limb Volume FluctuationR01HD060585 · NICHD · UNIVERSITY OF WASHINGTON · PI SANDERS, JOAN E. · 2009 to 2024
$6.6M
NICHD NIH HHS R01 HD060585
6 · The paper itself

Abstract

background: The volume of a prosthesis user's residual limb changes during the day and may affect the fit of the prosthesis. These changes must be managed by the user to prevent discomfort, skin breakdown, and falls.

objectives: The objectives were to test how activity, time of day, and intermittent doffing affected residual limb fluid volume in people with transtibial amputation. STUDY

design: Standardized, repeated measure (A-B-A) out-of-laboratory protocol.

methods: Participants with transtibial amputation completed three 6-h test sessions. Two sessions served as controls (A protocol) during which participants left their prosthesis donned, and one session was an intervention (B protocol) where participants doffed their prosthesis twice for 20 min during the 6 h of testing. Within-socket fluid volume was measured using a custom portable bioimpedance analysis system.

results: A total of 13 participants completed the study. The rate of limb fluid volume loss was higher early in the session compared with late in the session. Participants experienced less fluid volume loss during high activity than low activity. Socket users with pin suspension experienced less posterior fluid volume loss when they intermittently doffed their prosthesis. Intermittent doffing did not benefit limb fluid volume of mechanical vacuum and suction suspension users.

conclusion: High activity may reduce fluid volume loss compared with low activity. Intermittent doffing may provide volume accommodation for transtibial prosthesis users with pin suspension. CLINICAL RELEVANCE: Prosthetists should query their patients about the intensity of activity they conduct when advising them on limb volume management. Patients using sockets with pin suspension may be able to offset limb fluid volume loss by periodically doffing the prosthesis.

Indexed as

Artificial LimbsAdultAmputation StumpsAmputation, SurgicalAmputeesCircadian RhythmEdemaElectric ImpedanceExerciseFemaleHumansMaleMiddle AgedProsthesis FittingRisk AssessmentSampling Studiesbiomechanicsbiomechanics of prosthetic/orthotic devicesprosthetic designProsthetic interface mechanicsprostheticsskinskin stress

Identifiers

PMID30010494
PMCPMC7447527
OpenAlexW2884260266

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.