Evidence map›Paper›PMID 30010404›Full record

ArticleCancer biotherapy & radiopharmaceuticals2018

Evaluation of N-Succinimidyl S-Acetylthioacetate Ligand for Radiolabeling of Humanized Antibodies with

Kevin J H Allen, Rubin Jiao, Mackenzie E Malo, Ekaterina Dadachova

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biotherapy & radiopharmaceuticals, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kevin J H AllenDepartment of Pharmacy and Nutrition, University of Saskatchewan , Saskatoon, Canada .
Rubin JiaoDepartment of Pharmacy and Nutrition, University of Saskatchewan , Saskatoon, Canada .
Mackenzie E MaloDepartment of Pharmacy and Nutrition, University of Saskatchewan , Saskatoon, Canada .
Ekaterina DadachovaDepartment of Pharmacy and Nutrition, University of Saskatchewan , Saskatoon, Canada .
University of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radioimmunotherapy offers an effective way to direct ionizing radiation to cancer cells through attachment of radionuclides to antibodies while limiting negative effects of off-target irradiation. This, however, requires effective facile methods for attachment of therapeutic radionuclides onto antibodies. Herein, the authors report their efforts in evaluating N-succinimidyl S-acetylthioacetate (SATA), a commercially available reagent, for use as a bifunctional chelating agent (BCA) to attach

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedChelating AgentsFemaleHumansLigandsMelanomaMiceMice, Inbred C57BLRadioimmunotherapyRadioisotopesRadiopharmaceuticalsRheniumSuccinimidesSulfidesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedChelating AgentsLigandsN-hydroxysuccinimide S-acetylthioacetateRadioisotopesRadiopharmaceuticalsRheniumRhenium-188SuccinimidesSulfidesHPLCmelanomaradioimmunotherapyrheniumSATA

Identifiers

PMID30010404
PMCPMC6207158
OpenAlexW2883711541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.