Evidence map›Paper›PMID 30010214›Full record

ArticleJournal of cellular biochemistry2018

Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo.

Jungeun Yu, Stefano Zanotti, Lauren Schilling, Ernesto Canalis

Abstract read
In one paragraph

Article in Journal of cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jungeun YuDepartment of Orthopaedic Surgery, UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut.
Stefano ZanottiDepartment of Orthopaedic Surgery, UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut.
Lauren SchillingDepartment of Orthopaedic Surgery, UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut.
Ernesto CanalisDepartment of Orthopaedic Surgery, UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut.ORCID 0000-0002-9154-952X
UConn Health · US

Funding

Role of NFAT in the SkeletonR01AR068160 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2015 to 2019
$2.0M
NIAMS NIH HHS R01 AR068160
6 · The paper itself

Abstract

Nuclear factor of activated T cells (NFAT) c2 is important for the immune response and it compensates for NFATc1 for its effects on osteoclastogenesis, but its role in this process is not established. To study the function of NFATc2 in the skeleton, Nfatc2

Indexed as

AnimalsCell DifferentiationFemaleImmunoblottingMaleMiceMice, Mutant StrainsNFATC Transcription FactorsOsteoclastsOsteogenesisReverse Transcriptase Polymerase Chain ReactionX-Ray MicrotomographyNFATC Transcription Factorsbone remodelingbone resorptionnuclear factor of activated T cellsosteoclasts

Identifiers

PMID30010214
PMCPMC6195439
OpenAlexW2884705712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.