ArticleCancer medicine2018
Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status.
Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Socioeconomic status as a determinant of survival in glioblastoma: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Marital status and survival in cancer patients: A systematic review and meta-analysis.Cancer medicine · 2023Pooled it
- Development and Validation of the Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Patients With Synovial Sarcoma.Frontiers in endocrinology · 2021Trial
- Sex-Based Differences in Outcomes for Glioblastoma Patients Treated with Hypofractionated Chemoradiotherapy.Cancers · 2025Article
- The impact of socioeconomic status on glioma survival: a retrospective analysis.Cancer causes & control : CCC · 2025Article
- Survival Outcomes of U.S. Patients with CMML: A Two-Decade Analysis from the SEER Database.Medical sciences (Basel, Switzerland) · 2024Article
- Economic income and survival in patients affected by glioblastoma: A systematic review and meta-analysis.Neuro-oncology practice · 2024Review
- Racial and social-economic inequalities in systemic chemotherapy use among adult glioblastoma patients following surgery and radiotherapy.Scientific reports · 2024Article
- Clinical features and demographic characteristics of gestational trophoblastic neoplasia: Single center experience and the SEER database.Biomolecules & biomedicine · 2024Article
- Outcomes of Patients with Gastrointestinal Stromal Tumors in the Past Decade.Medical sciences (Basel, Switzerland) · 2023Article
- Primary Cardiac Sarcoma: Clinical Characteristics and Prognostic Factors over the Past 2 Decades.Diseases (Basel, Switzerland) · 2023Article
- Effectiveness of adjuvant chemotherapy for elderly patients with triple-negative breast cancer.Biomolecules & biomedicine · 2023Article
- Interaction between Age and Primary Site on Survival Outcomes in Primary GI Melanoma over the Past Decade.Medical sciences (Basel, Switzerland) · 2023Article
- Interaction between age and gender on survival outcomes in extramedullary multiple myeloma over the past two decades.World journal of clinical oncology · 2023Article
- Comparative analysis of the prognosis of external beam radiation therapy (EBRT) and EBRT plus brachytherapy for glioblastoma multiforme: a SEER population-based study.Radiation oncology (London, England) · 2022Article
- Sublobar resection versus lobectomy for patients with stage T1-2N0M0 pulmonary typical carcinoid tumours: a population-based propensity score matching analysis.Interactive cardiovascular and thoracic surgery · 2022Article
- Review
- Socioeconomic and demographic determinants of radiation treatment and outcomes in glioblastoma patients.Frontiers in neurology · 2022Article
- Cardiovascular Outcomes in the Patients With Colorectal Cancer: A Multi-Registry-Based Cohort Study of 197,699 Cases in the Real World.Frontiers in cardiovascular medicine · 2022Article
- Construction and validation of a nomogram model to predict the overall survival rate of esophageal cancer patients receiving neoadjuvant chemotherapy: A population-based study.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between marital status and glioblastoma multiforme (GBM) has not been addressed in depth. Here, we aimed to investigate the association between marital status and survival in GBM. We searched the Surveillance, Epidemiology, and End Results (SEER) database and extracted the data of eligible patients diagnosed with GBM after 2004. Marital status was classified as married, divorced/separated, widowed, and single. A Kaplan-Meier test was conducted to compare the survival curves of different groups. Multivariate Cox regression was performed to evaluate overall survival (OS) and cause-specific survival (CSS) in different groups. Subgroup analysis was applied according to demographics, typical education and income levels in the locale, and insurance status. A total of 30 767 eligible patients were included. The median OS values were 9, 7, 3, 9 months in married, divorced/separated, widowed, and single patients, respectively. After adjustment for other covariates, married patients had better OS and CSS than other patients had. In addition to marital status, demographic factors, disease progression factors, local educational level, and insurance status were also associated with survival in GBM. Furthermore, subgroup analyses revealed the protective effect of marriage in most of the comparisons. Notably, the protective effect of marriage becomes more and more apparent as time goes on. The advantageous effect of marriage on GBM survival is especially prominent in patients who are male, older than 60 years of age, White, or living in middle-income counties. In conclusion, marital status is an independent prognostic factor for GBM.
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