Evidence map›Paper›PMID 30009570›Full record

ArticlePhysiological reports2018

Curcumin supplementation mitigates NASH development and progression in female Wistar rats.

Rory P Cunningham, Mary P Moore, Angelique N Moore, James C Healy, Michael D Roberts, R Scott Rector, Jeffrey S Martin

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

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  17. Changes in Glutathione Content in Liver Diseases: An Update.Antioxidants (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rory P CunninghamResearch Service-Harry S Truman Memorial VA Hospital, Columbia, Missouri.
Mary P MooreResearch Service-Harry S Truman Memorial VA Hospital, Columbia, Missouri.
Angelique N MooreDepartment of Biomedical Sciences, Edward Via College of Osteopathic Medicine - Auburn Campus, Auburn, Alabama.
James C HealyDepartment of Biomedical Sciences, Edward Via College of Osteopathic Medicine - Auburn Campus, Auburn, Alabama.
Michael D RobertsDepartment of Biomedical Sciences, Edward Via College of Osteopathic Medicine - Auburn Campus, Auburn, Alabama.
R Scott RectorResearch Service-Harry S Truman Memorial VA Hospital, Columbia, Missouri.
Jeffrey S MartinDepartment of Biomedical Sciences, Edward Via College of Osteopathic Medicine - Auburn Campus, Auburn, Alabama.ORCID 0000-0001-6762-086X
Harry S. Truman Memorial Veterans' Hospital · USAuburn University · USEdward Via College of Osteopathic Medicine · US

Funding

Hepatic eNOS in the regulation of NASHI01BX003271 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI RANDY SCOTT RECTOR · 2017 to 2026
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BLRD VA I01 BX003271
6 · The paper itself

Abstract

Curcumin, a naturally occurring plant polyphenolic compound, may have beneficial effects in nonalcoholic steatohepatitis (NASH) development. We examined whether curcumin supplementation could be used in both prevention and treatment of NASH with fibrosis. Female Wistar rats were provided ad libitum access to a "western diet" (WD) high in fat (43% kcal), sucrose (29% kcal), and cholesterol (2% w/v), as well as 15% fructose drinking water. Intraperitoneal CC1

Indexed as

AnimalsAnti-Inflammatory AgentsAntioxidantsApolipoprotein B-100CollagenCurcuminDiet, High-FatFemaleGlutathioneNon-alcoholic Fatty Liver DiseaseOsteopontinRatsRats, WistarTumor Necrosis Factor-alphaAnti-Inflammatory AgentsAntioxidantsApolipoprotein B-100CollagenCurcuminGlutathioneOsteopontinSpp1 protein, ratTumor Necrosis Factor-alphaCurcumininflammationNASHsteatosis

Identifiers

PMID30009570
PMCPMC6046645
OpenAlexW2884835000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.