ArticleBiotechnology progress2018
A novel mammalian cell line development platform utilizing nanofluidics and optoelectro positioning technology.
Article in Biotechnology progress, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Streamlined stable CHO cell line development using droplet microfluidics with image-based monoclonality assessment.Bioprocess and biosystems engineering · 2026Article
- A high-throughput modular microfluidic platform for versatile functional assays at single-cell level.Microsystems & nanoengineering · 2026Article
- Identification of antigen-specific functional CD8iScience · 2025Article
- Accelerating biopharmaceutical cell line selection with label-free multimodal nonlinear optical microscopy and machine learning.Communications biology · 2025Article
- Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications.Immuno-oncology technology · 2024Review
- A nanowell platform to identify, sort and expand high antibody-producing cells.Scientific reports · 2024Article
- Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting.Nature biomedical engineering · 2024Article
- Antibodies, repertoires and microdevices in antibody discovery and characterization.Lab on a chip · 2024Review
- Mammalian cell growth characterisation by a non-invasive plate reader assay.Nature communications · 2024Article
- Suspendable Hydrogel Nanovials for Massively Parallel Single-Cell Functional Analysis and Sorting.ACS nano · 2022Article
- IL-2 secretion-based sorting of single T cells using high-throughput microfluidic on-cell cytokine capture.Lab on a chip · 2022Article
- Sorting single-cell microcarriers using commercial flow cytometers.SLAS technology · 2022Article
- Characterizing cell interactions at scale with made-to-order droplet ensembles (MODEs).Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones.Frontiers in bioengineering and biotechnology · 2022Review
- Recent advances of integrated microfluidic suspension cell culture system.Engineering biology · 2021Review
- Microfluidic chip-based single-cell cloning to accelerate biologic production timelines.Biotechnology progress · 2021Article
- Accelerating and de-risking CMC development with transposon-derived manufacturing cell lines.Biotechnology and bioengineering · 2021Article
- A machine learning Automated Recommendation Tool for synthetic biology.Nature communications · 2020Article
- Directed evolution approach to enhance efficiency and speed of outgrowth during single cell subcloning of Chinese Hamster Ovary cells.Computational and structural biotechnology journal · 2020Article
- Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring.Biotechnology and bioengineering · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Generating a highly productive cell line is resource intensive and typically involves long timelines because of the need to screen large numbers of candidates in protein production studies. This has led to miniaturization and automation strategies to allow for reductions in resources and higher throughput. Current approaches rely on the use of standard cell culture vessels and bulky liquid handling equipment. New nanofludic technologies offer novel solutions to surpass these limits, further miniaturizing cell culture volumes (10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.