Evidence map›Paper›PMID 30009527›Full record

ArticleClinical and experimental immunology2018

Tissue-resident memory T cells are epigenetically cytotoxic with signs of exhaustion in human urinary bladder cancer.

C A Hartana, E Ahlén Bergman, A Broomé, S Berglund, M Johansson, F Alamdari, T Jakubczyk, Y Huge, F Aljabery, K Palmqvist and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 57 citations in OpenAlex.

  1. CD8MedComm · 2026
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  12. Stem-like exhausted and memory CD8Nature reviews. Cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

C A HartanaKarolinska Institutet, Department of Medicine Solna, Unit of Immunology and Allergy, Stockholm, Sweden.
E Ahlén BergmanKarolinska Institutet, Department of Medicine Solna, Unit of Immunology and Allergy, Stockholm, Sweden.
A BrooméKarolinska Institutet, Department of Medicine Solna, Unit of Immunology and Allergy, Stockholm, Sweden.
S BerglundKarolinska Institutet, Department of Medicine Solna, Unit of Immunology and Allergy, Stockholm, Sweden.
M JohanssonDepartment of Urology, Sundsvall Hospital, Sundsvall, Sweden.
F AlamdariDepartment of Urology, Västmanland Hospital, Västerås, Sweden.
T JakubczykDepartment of Urology, Länssjukhuset Ryhov, Jönköping, Sweden.
Y HugeDepartment of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden.
F AljaberyDepartment of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden.
K PalmqvistDepartment of Surgery, Östersund County Hospital, Urology section, Östersund, Sweden.
B HolmströmDepartment of Urology, Akademiska University Hospital, Uppsala, Sweden.
H GliseKarolinska Institutet, Department of Medicine Solna, Unit of Immunology and Allergy, Stockholm, Sweden.
K RiklundDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden.
A SherifDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
O WinqvistKarolinska Institutet, Department of Medicine Solna, Unit of Immunology and Allergy, Stockholm, Sweden.
Karolinska Institutet · SELinköping University · SEUmeå University · SEÖstersunds Hospital · SESundsvall Municipality · SEUppsala University Hospital · SEVästmanlands sjukhus Västerås · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue-resident memory T (T

Indexed as

CD8-Positive T-LymphocytesCells, CulturedDNA MethylationHumansImmunologic MemoryImmunotherapyInterleukin-15PerforinProgrammed Cell Death 1 ReceptorProspective StudiesUrinary Bladder NeoplasmsIL15 protein, humanInterleukin-15PDCD1 protein, humanPerforinPRF1 protein, humanProgrammed Cell Death 1 ReceptorCD8-positive T lymphocytescell exhaustionDNA methylationperforintissue-resident memory T cellsurinary bladder neoplasms

Identifiers

PMID30009527
PMCPMC6156818
OpenAlexW2884158365

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.