Evidence map›Paper›PMID 30009506›Full record

ArticleJournal of biophotonics2019

Quantitative depolarization measurements for fiber-based polarization-sensitive optical frequency domain imaging of the retinal pigment epithelium.

Norman Lippok, Boy Braaf, Martin Villiger, Wang-Yuhl Oh, Benjamin J Vakoc, Brett E Bouma

Open access · greenAbstract read
In one paragraph

Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  2. Journal of biomedical optics · 2024
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  5. Journal of biomedical optics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Norman LippokHarvard Medical School, Boston, Massachusetts.
Boy BraafHarvard Medical School, Boston, Massachusetts.
Martin VilligerHarvard Medical School, Boston, Massachusetts.
Wang-Yuhl OhDepartment of Mechanical Engineering, KAIST, Daejeon, South Korea.
Benjamin J VakocHarvard Medical School, Boston, Massachusetts.
Brett E BoumaHarvard Medical School, Boston, Massachusetts.
Massachusetts General Hospital · USHarvard University · USKorea Advanced Institute of Science and Technology · KR

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
NIBIB NIH HHS P41 EB015903
6 · The paper itself

Abstract

A full quantitative evaluation of the depolarization of light may serve to assess concentrations of depolarizing particles in the retinal pigment epithelium and to investigate their role in retinal diseases in the human eye. Optical coherence tomography and optical frequency domain imaging use spatial incoherent averaging to compute depolarization. Depolarization depends on accurate measurements of the polarization states at the receiver but also on the polarization state incident upon and within the tissue. Neglecting this dependence can result in artifacts and renders depolarization measurements vulnerable to birefringence in the system and in the sample. In this work, we discuss the challenges associated with using a single input polarization state and traditional depolarization metrics such as the degree-of-polarization and depolarization power. We demonstrate quantitative depolarization measurements based on Jones vector synthesis and polar decomposition using fiber-based polarization-sensitive optical frequency domain imaging of the retinal pigment epithelium in a human eye.

Indexed as

HumansOptical ImagingOptical PhenomenaRetinal Pigment Epitheliumdepolarizationmedical imagingophthalmologyoptical coherence tomographypolarizationsingle-mode fiber

Identifiers

PMID30009506
PMCPMC6526942
OpenAlexW2883505494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.