Evidence map›Paper›PMID 30009475›Full record

ArticleCancer medicine2018

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study.

Lei Qin, Yi-Wei Kao, Yueh-Lung Lin, Bou-Yue Peng, Win-Ping Deng, Tsung-Ming Chen, Kuan-Chou Lin, Kevin Sheng-Po Yuan, Alexander T H Wu, Ben-Chang Shia and 1 more

Open access · goldAbstract read
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Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Lei QinSchool of Statistics, University of International Business and Economics, Beijing, China.
Yi-Wei KaoGraduate Institute of Business Administration, Fu Jen Catholic University, Taipei, Taiwan.
Yueh-Lung LinSchool of Mathematical Sciences, University of Nottingham Ningbo China, Ningbo, China.
Bou-Yue PengDepartment of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan.
Win-Ping DengGraduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei, Taiwan.
Tsung-Ming ChenDepartment of Otorhinolaryngology, Shuang-Ho Hospital, Taipei Medical University, Taipei, Taiwan.
Kuan-Chou LinDepartment of Oral and Maxillofacial Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Kevin Sheng-Po YuanDepartment of Otorhinolaryngology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Alexander T H WuPh.D. Program for Translational Medicine, Taipei Medical University, Taipei, Taiwan.
Ben-Chang ShiaCollege of Management, Taipei Medical University, Taipei, Taiwan.
Szu-Yuan WuInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-5637-558X
Taipei Medical University · TWWan Fang Hospital · TWFu Jen Catholic University · TWSun Yat-sen University · CNTaipei Medical University Hospital · TWTaipei Medical University-Shuang Ho Hospital · TWUniversity of International Business and Economics · CNUniversity of Nottingham Ningbo China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population-based database in Taiwan. MATERIALS AND

methodsWe selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non-RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow-up were identified.

resultsAmong 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95% confidence interval [CI]: 1.25-1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95% CI: 1.8-2.3), colon (aHR = 1.2, 95% CI: 1.1-1.4), liver (aHR = 1.1, 95% CI: 1-1.3), pancreas (aHR = 1.4, 95% CI: 1.1-1.7), skin (aHR = 1.4, 95% CI: 1.2-1.7), breast (aHR = 1.2, 95% CI: 1.1-1.4), and prostate (aHR = 1.5, 95% CI: 1.3-1.8), as well as hematologic cancers (aHR = 1.6, 95% CI: 1.3-1.9). A higher risk was observed for male patients (aHR = 1.35, 95% CI: 1.28-1.42) than for female patients (aHR = 1.25, 95% CI: 1.18-1.31) with RAS.

conclusionsRAS was associated with specific cancers. Susceptible RAS patients should be screened for specific cancers.

Indexed as

AdolescentAdultAgedCase-Control StudiesDatabases, FactualFemaleHumansMaleMiddle AgedNeoplasmsPrecancerous ConditionsProportional Hazards ModelsRecurrenceRisk AssessmentRisk FactorsSocioeconomic Factorscancercase-controlgenderrecurrent aphthous stomatitisrisk factor

Identifiers

PMID30009475
PMCPMC6089185
OpenAlexW2883624189

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.