ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018
National Institutes of Health Stroke Scale in patients with primary intracerebral hemorrhage.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guidelines for Neuroprognostication in Critically Ill Adults with Intracerebral Hemorrhage.Neurocritical care · 2024Guideline
- Cognitive impairment before and after intracerebral haemorrhage: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH-2 trial intracerebral hemorrhage population.European journal of neurology · 2021Trial
- Blood pressure variability and outcome in acute severe stroke: A post hoc analysis of CHASE-A randomized controlled trial.Journal of clinical hypertension (Greenwich, Conn.) · 2021Trial
- Article
- Evaluation of the CNS-LAND Score for ICU Mortality Prediction in Patients with Spontaneous Intracerebral Hemorrhage.Journal of clinical medicine · 2026Article
- Article
- Predictors of mortality of Hypertensive Intracerebral Hemorrhage (HICH) patients: a single centre study.BMC neurology · 2026Article
- Article
- Predictive factors for functional and motor recovery following spontaneous intracerebral haemorrhage.Journal of rehabilitation medicine · 2025Article
- Predictors of poor outcomes in patients with intracerebral hemorrhage.Frontiers in neurology · 2025Article
- Automated Extraction of Stroke Severity From Unstructured Electronic Health Records Using Natural Language Processing.Journal of the American Heart Association · 2024Article
- How much of the variance in functional outcome related to intracerebral hemorrhage volume is already apparent in neurological status at admission?Journal of neurology · 2024Article
- Automated Extraction of Stroke Severity from Unstructured Electronic Health Records using Natural Language Processing.medRxiv : the preprint server for health sciences · 2024Article
- Long-Term Functional Outcome in Patients With Isolated Thalamic Stroke: The KOSCO Study.Journal of the American Heart Association · 2024Article
- Predictive value of the dynamic systemic immune-inflammation index in the prognosis of patients with intracerebral hemorrhage: a 10-year retrospective analysis.Frontiers in neurology · 2024Article
- Article
- Statins and 90-Day Functional Performance and Survival in Patients with Spontaneous Intracerebral Hemorrhage.Journal of clinical medicine · 2023Article
- Validation of the National Institutes of Health Stroke Scale in Intracerebral Hemorrhage.Stroke (Hoboken, N.J.) · 2023Article
- Risk factors and a prediction model for the prognosis of intracerebral hemorrhage using cerebral microhemorrhage and clinical factors.Frontiers in neurology · 2023Article
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6 authors.
Funding
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Abstract
backgroundThe National Institutes of Health Stroke Scale (NIHSS) is able to predict mortality and functional outcome in patients with ischemic stroke. Its role in primary intracerebral hemorrhage (ICH) is not clear. The objective of our study was to investigate whether NIHSS is a reliable instrument of clinical monitoring and correlates with mortality and functional outcome in ICH.
methodsOne hundred fifty-six consecutive subjects with primary ICH were included. We evaluated NIHSS at admission. The functional state after a 30-day and a 3-month-long follow-up was assessed by the modified Rankin Scale (mRS). Spearman's rank correlation coefficient analysis was used for statistics. Sensitivity, specificity, positive predictive value, negative predictive value, global accuracy, and ROC curve were computed using the median score 7 as NIHSS cutoff and the score 4 as mRS cutoff.
resultsMedian NIHSS score at admission was 7 (16-4); the mean (± SD) was 10.82 (± 8.27). Thirty-two patients (20.5%) died within 30 days and other 22 (14.1%) within 3 months. The median mRS score at 3 months was 4 (6-1); the mean (± SD) was 3.38 (± 2.42). We found a statistically significant correlation between initial NIHSS score and mRS score after 30 days (0.74) and 3 months (0.66, p < 0.01). Sensitivity was 93.5 and 92.2%, specificity 82.3 and 69.6%, and GA 87.8 and 80.8%, respectively, at 1 and 3 months. The 1- and 3-month ROC curves comparing initial NIHSS and mRS showed a fitted area as 0.914 and 0.833, respectively.
conclusionsNIHSS is a reliable tool of clinical monitoring and correlates with 30-day and 3-month mortality and functional outcome in subjects with ICH.
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