Evidence map›Paper›PMID 30009333›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018

The serum level of inflammatory markers in chronic and episodic migraine: a case-control study.

Fahimeh Martami, Soodeh Razeghi Jahromi, Mansoureh Togha, Zeinab Ghorbani, Maryam Seifishahpar, Atoosa Saidpour

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 7 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 7 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
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  6. Pooled it
  7. Vitamin D in migraine headache: a comprehensive review on literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Pooled it
  8. Trial
  9. Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Trial
  10. Salivary inflammatory markers in tension type headache and migraine: the SalHead cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Trial
  11. Observational
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  14. Review
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  16. Association between serum high-sensitivity C-reactive protein levels and migraine: a REFORM study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Fahimeh MartamiHeadache Department, Iranian Center of Neurological Research¸ Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Soodeh Razeghi JahromiHeadache Department, Iranian Center of Neurological Research¸ Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mansoureh ToghaHeadache Department, Iranian Center of Neurological Research¸ Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Toghae@sina.tums.ac.ir.ORCID http://orcid.org/0000-0002-9368-6835
Zeinab GhorbaniHeadache Department, Iranian Center of Neurological Research¸ Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Maryam SeifishahparHeadache Department, Iranian Center of Neurological Research¸ Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Atoosa SaidpourDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
National Nutrition and Food Technology Research Institute · IRSina Hospital · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The exact mechanism of the migraine pathophysiology remained unclear. Although there are some reports showing low-grade inflammation in migraineurs, further studies are needed in this field. Thus, we designed a study to evaluate the serum levels of two main proinflammatory markers in migraine patients. In this case-control research, 43 migraine patients (23 chronic and 20 episodic migraineurs) and 40 age-sex-matched headache-free controls were studied. Demographic, dietary, and anthropometric data, headache characteristics, and serum C-reactive proteins (CRP) and tumor necrosis factor-alpha (TNF-α) assessments were collected. The mean ± SD age of the case and control groups were 36.98 ± 9.91 and 34.84 ± 9.75 years respectively. Compared to control subjects, both episodic and chronic migraineurs had significantly higher median levels of TNF-α (0.24, 0.95, and 1.90 pg/ml, respectively; P value < 0.001). Also, we observed a positive association between the TNF-α levels and the odds of having migraine after considering gender, age, body mass index, and dietary intakes of energy, carbohydrate, protein, fat, and mono and poly unsaturated fatty acids in the multivariable regression models (OR = 2.15; 95% CI 1.31-3.52; P value < 0.001). However, no significant association was demonstrated between migraine and serum CRP (OR = 2.91; 95% CI 0.87-9.78; P value = 0.08). These findings supported that inflammatory state could be related to the pathogenesis of migraine and it can thus be suggested that this effect might be beyond migraine progression. Further detailed studies are needed to investigate the importance of these findings in the pathogenesis of migraine headache.

Indexed as

AdultBiomarkersCase-Control StudiesC-Reactive ProteinFemaleHumansMaleMigraine DisordersTumor Necrosis Factor-alphaBiomarkersC-Reactive ProteinTumor Necrosis Factor-alphaC-reactive proteins (CRP)HeadacheInflammationMigraineTumor necrosis factor-alpha (TNF-α)

Identifiers

PMID30009333
OpenAlexW2884505804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.