ReviewBurns & trauma2018
Tissue engineering of skin and regenerative medicine for wound care.
Review in Burns & trauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Human Placental Mesenchymal Stem Cell-Derived Exosomes in Wound Healing and Scar Therapy: A Systematic Review and Meta-analysis.Aesthetic surgery journal · 2026Pooled it
- Dermal Templates Support Epidermal Regeneration and Maturation Regardless of Cell Donor Age.Tissue engineering. Part A · 2026Article
- Use of Skeletal External Fixation to Improve Cultured Epidermal Autograft Outcomes in Lower Extremity Burns.European burn journal · 2026Article
- Biomimetic Dermal Substitutes for Skin Reconstruction: Advances in Scaffold Design, Biological Integration, and Clinical Performance.Journal of functional biomaterials · 2026Review
- Experimental Burn Induction in Laboratory Animals: A Scoping Review of Methods, Reproducibility, Operator-Dependent Variability, and Relevance to Soft Tissue Reconstruction and Repair.Bioengineering (Basel, Switzerland) · 2026Review
- Biomaterials' Role in Improving Patient Care from Drug Testing and Delivery to Theragnostics and Regenerative Medicine.Journal of functional biomaterials · 2026Review
- Predicting Nutritional Risk in Elderly Patients With Community-Acquired Pressure Injury: A Noninvasive Model Integrating Age, Intake, BMI, and Braden Score.International wound journal · 2026Article
- A bioinspired enzyme-responsive hydrogel for spatiotemporal control of macrophage reprogramming in chronic wounds.Frontiers in bioengineering and biotechnology · 2026Article
- Potential Application of Plant-Derived Extracellular Vesicles in Treatment of Burn Wounds.International journal of nanomedicine · 2026Review
- Postnatal Maxillofacial "Developing" Decellularized Extracellular Matrix Orchestrates Hierarchical Cross-Organ Regeneration via Macrophage Integrin αvβ5-Mediated Efferocytosis-Driven Developmental Recapitulation.Research (Washington, D.C.) · 2026Article
- Differential Effect of P2X7 Receptors on Proliferation and Migration of Human Keratinocytes and Dermal Fibroblasts.International journal of molecular sciences · 2025Article
- Electrospun PEDOT-Based Meshes for Skin Regeneration.Polymers · 2025Article
- Decellularized extracellular matrix-loaded exosome hydrogel for cell-free tracheal scaffold in tracheal defect reconstruction and repair.Journal of nanobiotechnology · 2025Article
- Nanomedicine-based immunotherapy for tissue regeneration.Burns & trauma · 2025Review
- Acellular foreskin dermal matrix is efficient in supporting the growth of urothelial cells derived from hypospadias patients.Frontiers in pediatrics · 2025Article
- Reframing chronic wound therapy: from growth factor delivery to regenerative immuno-engineering.Frontiers in immunology · 2025Article
- Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation.Frontiers in bioengineering and biotechnology · 2025Review
- Recent advances in the role of neuroregulation in skin wound healing.Burns & trauma · 2025Review
- Acellular dermal matrices in reconstructive surgery; history, current implications and future perspectives for surgeons.World journal of clinical cases · 2024Review
- Chitosan alchemy: transforming tissue engineering and wound healing.RSC advances · 2024Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Engineering of biologic skin substitutes has progressed over time from individual applications of skin cells, or biopolymer scaffolds, to combinations of cells and scaffolds for treatment, healing, and closure of acute and chronic skin wounds. Skin substitutes may be categorized into three groups: acellular scaffolds, temporary substitutes containing allogeneic skin cells, and permanent substitutes containing autologous skin cells. Combined use of acellular dermal substitutes with permanent skin substitutes containing autologous cells has been shown to provide definitive wound closure in burns involving greater than 90% of the total body surface area. These advances have contributed to reduced morbidity and mortality from both acute and chronic wounds but, to date, have failed to replace all of the structures and functions of the skin. Among the remaining deficiencies in cellular or biologic skin substitutes are hypopigmentation, absence of stable vascular and lymphatic networks, absence of hair follicles, sebaceous and sweat glands, and incomplete innervation. Correction of these deficiencies depends on regulation of biologic pathways of embryonic and fetal development to restore the full anatomy and physiology of uninjured skin. Elucidation and integration of developmental biology into future models of biologic skin substitutes promises to restore complete anatomy and physiology, and further reduce morbidity from skin wounds and scar. This article offers a review of recent advances in skin cell thrapies and discusses the future prospects in cutaneous regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.