ArticleCanadian journal of gastroenterology & hepatology2018
Macroscopic Portal Vein Thrombosis in HCC Patients.
Article in Canadian journal of gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Liver transplant for large hepatocellular carcinoma in Malatya: The role of gamma glutamyl transferase and alpha-fetoprotein, a retrospective cohort study.World journal of gastrointestinal surgery · 2020Trial
- Article
- Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Discordance among aggressiveness characteristics of hepatocellular carcinoma: Portal vein thrombosis and multifocality, related to tumor size, but not to serum alpha-fetoprotein level.Liver research (Beijing, China) · 2023Article
- Impact of body mass index in patients receiving atezolizumab plus bevacizumab for hepatocellular carcinoma.Hepatology international · 2023Article
- Portal vein thrombosis in patients with hepatocellular carcinoma and early cirrhosis-prevalence and risk factors.Ecancermedicalscience · 2023Article
- A study of the clinical profile, predictors, prognostic features, and survival of patients with hepatocellular carcinoma having macroscopic portal vein tumor thrombosis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Article
- Usefulness of Imaging and Biological Tools for the Characterization of Portal Vein Thrombosis in Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2022Article
- Microscopic Portal Vein Invasion in Relation to Tumor Focality and Dimension in Patients with Hepatocellular Carcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia.International journal of hepatology · 2022Article
- Surgical management in hepatocellular carcinoma with portal vein tumour thrombosis: is this the end of the road or a chance to expand the criteria for resectability?Przeglad gastroenterologiczny · 2022Review
- Predictors of Macrovascular Invasion and Extrahepatic Metastasis in Treatment Naive Hepatocellular Carcinoma: When Is [Nuclear medicine and molecular imaging · 2021Article
- Relationships Between Indices of Tumor Aggressiveness in Hepatocellular Carcinoma.Journal of gastrointestinal cancer · 2021Article
- Tumor multifocality and serum albumin levels can identify groups of patients with hepatocellular carcinoma and portal vein thrombosis having distinct survival outcomes.Annals of medicine and surgery (2012) · 2021Article
- Portal Vein Thrombosis and Markers of Inflammation in Hepatocellular Carcinoma.Journal of gastrointestinal cancer · 2020Article
- Article
- Review of therapies for intermediate and advanced stage hepatocellular carcinoma, not suitable for curative therapies: a rapidly changing landscape.Hepatoma research · 2019Article
- Adjuvant trans-arterial chemoembolization after hepatectomy significantly improves the prognosis of low-risk patients with R0-stage hepatocellular carcinoma.Cancer management and research · 2019Article
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30 authors.
Funding
Abstract
Macroscopic portal vein invasion (PVT) by hepatocellular carcinoma (HCC) in the liver is one of the most important negative prognostic factors for HCC patients. The characteristics of a large cohort of such patients were examined. We found that the percent of patients with PVT significantly increased with increasing maximum tumor diameter (MTD), from 13.7% with tumors of MTD <5cm to 56.4% with tumors of MTD >10cm. There were similar numbers of HCC patients with very large tumors with and without PVT. Thus, MTD alone was insufficient to explain the presence of PVT, as were high AFP levels, since less than 50% of high AFP patients had PVT. However, the percent of patients with PVT was also found to significantly increase with increasing blood alpha-fetoprotein (AFP) levels and tumor multifocality. A logistic regression model that included these 3 factors together showed an odds ratio of 17.9 for the combination of MTD>5.0cm plus tumor multifocality plus elevated AFP, compared to low levels of these 3 parameters. The presence or absence of macroscopic PVT may therefore represent different HCC aggressiveness phenotypes, as judged by a significant increase in tumor multifocality and AFP levels in the PVT positive patients. Factors in addition to MTD and AFP must also contribute to PVT development.
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