Evidence map›Paper›PMID 30009130›Full record

ArticleNeuroImage. Clinical2018

The neuropsychological profiles and semantic-critical regions of right semantic dementia.

Keliang Chen, Junhua Ding, Biying Lin, Lin Huang, Le Tang, Yanchao Bi, Zaizhu Han, Yingru Lv, Qihao Guo

Abstract read
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Executive functions in primary progressive aphasia: A meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Pooled it
  3. Multimodal semantic knowledge of emotion concepts in frontotemporal dementia.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keliang ChenDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Junhua DingState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Biying LinDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Lin HuangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Le TangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Yanchao BiState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Zaizhu HanState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Yingru LvDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: xxzlyr@163.com.
Qihao GuoDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: dr.guoqihao@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Previous literature has revealed that the anterior temporal lobe (ATL) is the semantic hub of left-sided or mixed semantic dementia (SD), whilst the semantic hub of right-sided SD has not been examined. Methods: Seventeen patients with right-sided SD, 18 patients with left-sided SD and 20 normal controls (NC) underwent neuropsychological assessments and magnetic resonance imaging scans. We investigated the relationship between the degree of cerebral atrophy in the whole brain and the severity of semantic deficits in left and right-sided SD samples, respectively. Results: We found the semantic deficits of right-sided SD patients were related to bilateral fusiform gyri and left temporal pole, whilst the left fusiform gyrus correlated with the semantic performance of left-sided SD patients. Moreover, all the findings couldn't be accounted for by total gray matter volume (GMV) or general cognitive degradation of patients. Discussion: These results provide novel evidence for the current semantic theory, that the important regions for semantic processing include both anterior and posterior temporal lobes.

Indexed as

AgedFemaleFrontotemporal DementiaFunctional LateralityHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsTemporal LobeLaterality of brain atrophyLesion-behavior mappingSemantic deficitsSemantic dementia

Identifiers

PMID30009130
PMCPMC6041419

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.