Evidence map›Paper›PMID 30009128›Full record

ArticleNeuroImage. Clinical2018

Amyloid pathology fingerprint differentiates post-traumatic stress disorder and traumatic brain injury.

Abdalla Z Mohamed, Paul Cumming, Hussein Srour, Tamara Gunasena, Aya Uchida, Courtney Nicole Haller, Fatima Nasrallah, Department of Defense Alzheimer's Disease Neuroimaging Initiative

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Abdalla Z MohamedQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.
Paul CummingSchool of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, QLD 4059, Australia; QIMR-Berghofer Institute, Brisbane, QLD 4006, Australia.
Hussein SrourQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.
Tamara GunasenaSchool of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Aya UchidaSchool of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Courtney Nicole HallerSchool of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Fatima NasrallahQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: f.nasrallah@uq.edu.au.
Department of Defense Alzheimer's Disease Neuroimaging Initiative
University of Queensland · AUQueensland University of Technology · AU

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Introduction: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are risk factors for early onset of Alzheimer's disease (AD) and may accelerate the progression rate of AD pathology. As amyloid-beta (Aβ) plaques are a hallmark of AD pathology, we hypothesized that TBI and PTSD might increase Aβ accumulation in the brain. Methods: We examined PET and neuropsychological data from Vietnam War veterans compiled by the US Department of Defense Alzheimer's Disease Neuroimaging Initiative, to examine the spatial distribution of Aβ in male veterans' who had experienced a TBI and/or developed PTSD. Subjects were classified into controls, TBI only, PTSD only, and TBI with PTSD (TBI_PTSD) groups and data were analyzed using both voxel-based and ROI-based approaches. Results: Compared to controls, all three clinical groups showed a pattern of mainly increased referenced standard uptake values (SUVR) for the amyloid tracer [ Conclusion: These results suggest that both TBI and PTSD are substantial risk factors for cognition decline and increased Aβ deposition resembling that in AD. In addition, both PTSD and TBI_PTSD have a different pathways of Aβ accumulation.

Indexed as

AgedAmyloid beta-PeptidesBrain Injuries, TraumaticDiagnosis, DifferentialDisease ProgressionHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingNeuropsychological TestsPositron-Emission TomographyStress Disorders, Post-Traumatictau ProteinsAmyloid beta-Peptidestau ProteinsAlzheimer's diseaseAmyloidDepartment of Defense Alzheimer's Disease Neuroimaging Initiative (DOD-ADNI)PETPost-traumatic stress disorderTraumatic brain injury

Identifiers

PMID30009128
PMCPMC6041560
OpenAlexW2805758269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.