Evidence map›Paper›PMID 30009127›Full record

ArticleNeuroImage. Clinical2018

The effect of tDCS on functional connectivity in primary progressive aphasia.

Bronte N Ficek, Zeyi Wang, Yi Zhao, Kimberly T Webster, John E Desmond, Argye E Hillis, Constantine Frangakis, Andreia Vasconcellos Faria, Brian Caffo, Kyrana Tsapkini

Erratum issued 2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 8 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03887481 narecruitingnot on this mapstarted 2022, after this paper: background citation

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Aphasic AD (Logopenic Variant PPA)

TypeinterventionalSponsorJohns Hopkins UniversityRan2022 to 2027Enrolled60ConditionsLogopenic Progressive Aphasia, Primary Progressive AphasiaArmsHigh-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment
NCT04122001 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

Transcranial Direct Current Stimulation in Typical and Atypical Alzheimer's Disease

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2026Enrolled90ConditionsAlzheimer Disease, Early Onset, Atypical Alzheimer's Disease, Logopenic Progressive AphasiaArmsActive, in-person HD-tDCS or active remote tDCS, Sham, Word List Learning Intervention (WordLLI)
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 8 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bronte N FicekDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Zeyi WangDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 21287, USA.
Yi ZhaoDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 21287, USA.
Kimberly T WebsterDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
John E DesmondDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Argye E HillisDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Cognitive Science, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Constantine FrangakisDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 21287, USA; Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Andreia Vasconcellos FariaDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Brian CaffoDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 21287, USA.
Kyrana TsapkiniDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Cognitive Science, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: tsapkini@jhmi.edu.
Johns Hopkins University · US

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Rehabilitation and Prophylaxis of Anomia in Primary Progressive AphasiaR01DC011317 · NIDCD · GEORGETOWN UNIVERSITY · PI FRIEDMAN, RHONDA B, MEYER, AARON M · 2011 to 2021
$6.4M
Effects of transcranial direct current stimulation in spoken and written production in primary progressive aphasiaR01DC014475 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2015 to 2019
$4.1M
NIA NIH HHS P50 AG005146NIBIB NIH HHS P41 EB015909NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC011317NIDCD NIH HHS R01 DC014475
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is an innovative technique recently shown to improve language outcomes even in neurodegenerative conditions such as primary progressive aphasia (PPA), but the underlying brain mechanisms are not known. The present study tested whether the additional language gains with repetitive tDCS (over sham) in PPA are caused by changes in functional connectivity between the stimulated area (the left inferior frontal gyrus (IFG)) and the rest of the language network. We scanned 24 PPA participants (11 female) before and after language intervention (written naming/spelling) with a resting-state fMRI sequence and compared changes before and after three weeks of tDCS or sham coupled with language therapy. We correlated changes in the language network as well as in the default mode network (DMN) with language therapy outcome measures (letter accuracy in written naming). Significant tDCS effects in functional connectivity were observed between the stimulated area and other language network areas and between the language network and the DMN. TDCS over the left IFG lowered the connectivity between the above pairs. Changes in functional connectivity correlated with improvement in language scores (letter accuracy as a proxy for written naming) evaluated before and after therapy. These results suggest that one mechanism for anodal tDCS over the left IFG in PPA is a decrease in functional connectivity (compared to sham) between the stimulated site and other posterior areas of the language network. These results are in line with similar decreases in connectivity observed after tDCS over the left IFG in aging and other neurodegenerative conditions.

Indexed as

AgedAphasia, Primary ProgressiveBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetTranscranial Direct Current StimulationTreatment OutcomeFunctional connectivityNeurodegenerative diseasesPrimary progressive aphasia (PPA)Resting-state fMRI (rsfMRI)Transcranial direct current stimulation (tDCS)

Identifiers

PMID30009127
PMCPMC6041563
OpenAlexW2804968933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.