Evidence map›Paper›PMID 30009053›Full record

ArticleJournal of advanced research2018

Butenafine and analogues: An expeditious synthesis and cytotoxicity and antifungal activities.

Ana María Garzón Porras, Bruna Silva Terra, Taniris Cafiero Braga, Thais Furtado Ferreira Magalhães, Cleide Viviane Buzanello Martins, Danielle Letícia da Silva, Ludmila Matos Baltazar, Ludmila Ferreira Gouveia, Gustavo José Cota de Freitas, Daniel Assis Santos and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Accelerated Cobalt-CatalyzedMolecules (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Ana María Garzón PorrasDepartamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Bruna Silva TerraDepartamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Taniris Cafiero BragaDepartamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Thais Furtado Ferreira MagalhãesDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Cleide Viviane Buzanello MartinsDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
Danielle Letícia da SilvaDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Ludmila Matos BaltazarDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Ludmila Ferreira GouveiaDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Gustavo José Cota de FreitasDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Daniel Assis SantosDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Maria Aparecida Resende-StoianoffDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Beth Burgwyn FuchsDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
Eleftherios MylonakisDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
Rossimiriam Pereira de FreitasDepartamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Ângelo de FátimaDepartamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais · BRRhode Island Hospital · USBrown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of fungal infections is considered a serious public health problem worldwide. The limited number of antimycotic drugs available to treat human and animal mycosis, the undesirable side effects and toxicities of the currently available drugs, and the emergence of fungal resistance emphasizes the urgent need for more effective antimycotic medicines. In this paper, we describe a rapid, simple, and efficient synthetic route for preparation of the antifungal agent butenafine on a multigram scale. This novel synthetic route also facilitated the preparation of 17 butenafine analogues using Schiff bases as precursors in three steps or less. All the synthesized compounds were evaluated against the yeast,

Indexed as

Antifungal activityButenafineMicrowave-assisted synthesisMultigram-scale synthesisSchiff baseTrichophyton rubrum

Identifiers

PMID30009053
PMCPMC6041462
OpenAlexW2809153635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.