ArticleOncology letters2018
Correlation between miR-222 and uterine cancer and its prognostic value.
Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Deregulated microRNAs Involved in Prostate Cancer Aggressiveness and Treatment Resistance Mechanisms.Cancers · 2023Review
- miR‑222 induces apoptosis in human intervertebral disc nucleus pulposus cells by targeting Bcl‑2.Molecular medicine reports · 2019Article
- Knockdown of miR-222 inhibits inflammation and the apoptosis of LPS-stimulated human intervertebral disc nucleus pulposus cells.International journal of molecular medicine · 2019Article
- MicroRNAs in Female Malignancies.Cancer informatics · 2019Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relationship between the expression of miR-222 and uterine cancer was investigated to explore its prognostic value. A total of 66 patients with uterine cancer diagnosed by pathological examination in Dongying People's Hospital were enrolled from March 2014 to October 2016. Uterine cancer and adjacent tissues were collected, and the expression of miR-222 in the tissues was detected by stem-loop RT-PCR. The relationship between miR-222 expression and various clinicopathological features of uterine cancer was analyzed. All the patients were followed up to record the survival conditions. The results revealed that stem-loop RT-PCR method could specifically amplify miR-222. The expression of miR-222 in uterine cancer tissues was significantly upregulated compared with that in adjacent tissues (p<0.05). The expression level of miR-222 was significantly increased with the increase of degree of tumor differentiation (p<0.05). The expression of miR-222 in uterine cancer tissue was not significantly correlated with patients age, tumor size, gross tumor type, pathological type and FIGO stage (p>0.05). There was a significant negative correlation between the expression of miR-222 and the survival of patients with uterine cancer. In conclusion, the expression of miR-222 in uterine cancer tissues was significantly upregulated in uterine cancer and negatively correlated with prognosis. miR-222 may play a pivotal role in the development and progression of uterine cancer. It is expected that miR-222 will be an indicator and target for the treatment and prognosis of uterine cancer.
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