ReviewFrontiers in endocrinology2018
Impact of Maternal Age on Oocyte and Embryo Competence.
Review in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
232 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Associations between adherence to a Mediterranean diet and assisted reproductive techniques outcomes: a systematic review.European journal of public health · 2025Pooled it
- Effects of emotions on IVF/ICSI outcomes in infertile women: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Endocrine and regenerative mechanisms of adipose-derived stem cells in female infertility.Frontiers in endocrinology · 2025Pooled it
- Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Recombinant human luteinizing hormone co-treatment in ovarian stimulation for assisted reproductive technology in women of advanced reproductive age: a systematic review and meta-analysis of randomized controlled trials.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.Journal of ovarian research · 2025Trial
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Dual effects of anti-Müllerian hormone on ovarian response and fertilization in assisted reproductive technology cycles: a retrospective cohort study.Obstetrics & gynecology science · 2026Article
- Sleep Disorders and the Influence of Maternal Age in Young Children With Autism Spectrum Disorder: A Retrospective Cross-sectional Study.Journal of autism and developmental disorders · 2026Article
- Maternal Morbidity and Adverse Fetal Outcomes in a Prospective North Indian Pregnancy Cohort.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Small Vulnerable Newborns Among Venezuelan Immigrants in Colombia Between 2018 and 2022.Journal of immigrant and minority health · 2026Article
- Ovarian Extracellular Matrix Mechanics Regulate Oocyte-Follicle Interactions During Female Reproductive Aging.Aging cell · 2026Article
- Empty Follicle Syndrome: Current Therapeutic Approaches and the Role of Triggering Agents in Assisted Reproductive Technology.Medical sciences (Basel, Switzerland) · 2026Review
- Mouse oocyte phenotypes differ in blastocyst response to resveratrol and vitamin B12.Reproduction & fertility · 2026Article
- From Cytoskeletal Remodeling to Oocyte Quality: The Emerging Role of Mechanics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Declines in ovarian reserve associated with ambient ozone exposure: mediating role of lipid profile.Lipids in health and disease · 2026Article
- A predictive model for high-quality blastocyst formation using Day 3 morphological scores in women of advanced maternal age.BMC pregnancy and childbirth · 2026Article
- [Association between periconception maternal cold and heat exposure and the risk of congenital heart disease in offspring in China].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Review
172 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The overall success of human reproduction, either spontaneously or after IVF, is highly dependent upon maternal age. The main reasons for age-related infertility include reduced ovarian reserve and decreased oocyte/embryo competence due to aging insults, especially concerning an increased incidence of aneuploidies and possibly decreased mitochondrial activity. Age-related chromosomal abnormalities mainly arise because of meiotic impairments during oogenesis, following flawed chromosome segregation patterns such as non-disjunction, premature separation of sister chromatids, or the recent reverse segregation. In this review, we briefly discuss the main mechanisms putatively impaired by aging in the oocytes and the deriving embryos. We also report the main strategies proposed to improve the management of advanced maternal age women in IVF: fertility preservation through oocyte cryopreservation to prevent aging; optimization of the ovarian stimulation and enhancement of embryo selection to limit its effects; and oocyte donation to circumvent its consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.