Evidence map›Paper›PMID 30008672›Full record

ArticleFrontiers in physiology2018

Genetic Variation in Acid Ceramidase Predicts Non-completion of an Exercise Intervention.

Lauren S Lewis, Kim M Huffman, Ira J Smith, Mark P Donahue, Cris A Slentz, Joseph A Houmard, Monica J Hubal, Eric P Hoffman, Elizabeth R Hauser, Ilene C Siegler and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Frailty and genetics: linking molecular aging to clinical vulnerability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Review
  2. Article
  3. Race and sex differences in dropout from the STRRIDE trials.Frontiers in sports and active living · 2023
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Lauren S LewisDepartment of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, United States.
Kim M HuffmanDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States.
Ira J SmithDivision of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
Mark P DonahueDivision of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
Cris A SlentzDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States.
Joseph A HoumardHuman Performance Laboratory, East Carolina University, Greenville, NC, United States.
Monica J HubalChildren's Genetic Medical Research Center, Children's National Medical Center, Washington, DC, United States.
Eric P HoffmanChildren's Genetic Medical Research Center, Children's National Medical Center, Washington, DC, United States.
Elizabeth R HauserDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States.
Ilene C SieglerDivision of Behavioral Medicine, Department of Psychiatry, Duke University School of Medicine, Durham, NC, United States.
William E KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States.
Duke University · USChildren's National · USDurham VA Medical Center · USEast Carolina University · US

Funding

Pilot Project for the DTMI CRA ProgramUL1RR024128 · NCRR · DUKE UNIVERSITY · PI CALIFF, ROBERT M · 2006 to 2010
$48.1M
The Genetics Of Biobehavioral Risk Factors For CVDP01HL036587 · NHLBI · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 1986 to 2020
$35.9M
PERIPHERAL EFFECTS OF EXERCISE ON CARDIOVASCULAR HEALTHR01HL057354 · NHLBI · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 1998 to 2008
$5.5M
Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistanceR01AG028930 · NIA · DUKE UNIVERSITY · PI MUOIO, DEBORAH M · 2006 to 2010
$2.0M
Mechanisms of Insulin Resistance in Rheumatoid ArthritisK23AR054904 · NIAMS · DUKE UNIVERSITY · PI HUFFMAN, KIM M. · 2008 to 2012
$354k
Molecular remodeling of muscle after exercise trainingF32AR052596 · NIAMS · CHILDREN'S RESEARCH INSTITUTE · PI HUBAL, MONICA J · 2006 to 2009
$139k
NCRR NIH HHS UL1 RR024128NHLBI NIH HHS P01 HL036587NHLBI NIH HHS R01 HL057354NIAMS NIH HHS F32 AR052596NIAMS NIH HHS K23 AR054904NIA NIH HHS R01 AG028930
6 · The paper itself

Abstract

Genetic variation is associated with a number of lifestyle behaviours; it may be associated with adherence and individual responses to exercise training. We tested single nucleotide polymorphisms (SNPs) in the acid ceramidase gene (

Indexed as

behavioural lifestyle interventionsceramideexercise adherencemetabolismSTRRIDE

Identifiers

PMID30008672
PMCPMC6034073
OpenAlexW2806731728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.