Evidence map›Paper›PMID 30008663›Full record

ArticleFrontiers in cellular neuroscience2018

Human Cortical Pyramidal Neurons: From Spines to Spikes via Models.

Guy Eyal, Matthijs B Verhoog, Guilherme Testa-Silva, Yair Deitcher, Ruth Benavides-Piccione, Javier DeFelipe, Christiaan P J de Kock, Huibert D Mansvelder, Idan Segev

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
5.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 152 citations in OpenAlex.

  1. Article
  2. Article
  3. Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  19. Hydrogen Sulfide (HInternational journal of molecular sciences · 2025
    Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Guy EyalDepartment of Neurobiology, Hebrew University of Jerusalem, Jerusalem, Israel.
Matthijs B VerhoogDepartment of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Guilherme Testa-SilvaDepartment of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Yair DeitcherEdmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
Ruth Benavides-PiccioneDepartamento de Neurobiología Funcional y de Sistemas, Instituto Cajal (CSIC), and Laboratorio Cajal de Circuitos Corticales (CTB), Universidad Politécnica de Madrid, Madrid, Spain.
Javier DeFelipeDepartamento de Neurobiología Funcional y de Sistemas, Instituto Cajal (CSIC), and Laboratorio Cajal de Circuitos Corticales (CTB), Universidad Politécnica de Madrid, Madrid, Spain.
Christiaan P J de KockDepartment of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Huibert D MansvelderDepartment of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Idan SegevDepartment of Neurobiology, Hebrew University of Jerusalem, Jerusalem, Israel.
Amsterdam Neuroscience · NLHebrew University of Jerusalem · ILInstituto Cajal · ESUniversidad Politécnica de Madrid · ES

Funding

A multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2M
NIMH NIH HHS U01 MH114812
6 · The paper itself

Abstract

We present detailed models of pyramidal cells from human neocortex, including models on their excitatory synapses, dendritic spines, dendritic NMDA- and somatic/axonal

Indexed as

compartmental modelingcortical excitatory synapsesdendritic spineshuman pyramidal cellsmulti objective optimizationneuron computationnon-linear dendrites

Identifiers

PMID30008663
PMCPMC6034553
OpenAlexW2953248462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.