ArticleNeuron2018
A Dedicated Population for Reward Coding in the Hippocampus.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 237 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
237 citing papers in PubMed.
- GABAergic subiculum-medial entorhinal projection in mice and rats.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Goal-directed hippocampal theta sweeps during memory-guided navigation.Nature neuroscience · 2026Article
- Article
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Prefrontal-thalamic goal states organize spatially aligned hippocampal maps.Nature communications · 2026Article
- Habit and the hippocampus: Model-based spatial representations without outcome-sensitive control.bioRxiv : the preprint server for biology · 2026Article
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.Research square · 2026Article
- A neuro-behavioural model of neophobia.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Place and behavioral modulation of hippocampal neurons during immobility.Nature communications · 2026Article
- Was the fruit in front of me or near the river? Biological relevance and reference frame preferences in object-location memory across the lifespan.Psychonomic bulletin & review · 2026Article
- Article
- From peripersonal space to cognitive maps: An evolutionary perspective.Progress in neurobiology · 2026Review
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.bioRxiv : the preprint server for biology · 2026Article
- Transformations of the spatial activity manifold convey aversive information in CA3.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Simple input-output dependencies explain neuronal activity.Nature physics · 2026Article
- Rearing and Head Scanning as Functionally Equivalent Information-Seeking Behaviors.bioRxiv : the preprint server for biology · 2026Article
- The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations.Nature neuroscience · 2026Article
177 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on byTreasure hunt.2018
Authors and funding
2 authors.
Funding
Abstract
The hippocampus plays a critical role in goal-directed navigation. Across different environments, however, hippocampal maps are randomized, making it unclear how goal locations could be encoded consistently. To address this question, we developed a virtual reality task with shifting reward contingencies to distinguish place versus reward encoding. In mice performing the task, large-scale recordings in CA1 and subiculum revealed a small, specialized cell population that was only active near reward yet whose activity could not be explained by sensory cues or stereotyped reward anticipation behavior. Across different virtual environments, most cells remapped randomly, but reward encoding consistently arose from a single pool of cells, suggesting that they formed a dedicated channel for reward. These observations represent a significant departure from the current understanding of CA1 as a relatively homogeneous ensemble without fixed coding properties and provide a new candidate for the cellular basis of goal memory in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.