Evidence map›Paper›PMID 30008292›Full record

ArticleCell host & microbe2018

The Stringent Response Determines the Ability of a Commensal Bacterium to Survive Starvation and to Persist in the Gut.

Whitman B Schofield, Maria Zimmermann-Kogadeeva, Michael Zimmermann, Natasha A Barry, Andrew L Goodman

Abstract read
In one paragraph

Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. High-throughput analyses ofGut microbes · 2026
    Article
  2. Review
  3. Article
  4. mSphere · 2026
    Article
  5. Article
  6. Article
  7. Aspartate aminotransferase is required forInfection and immunity · 2026
    Article
  8. Article
  9. Aspartate aminotransferase is required forbioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Host-microbiome mutualism drives urea carbon salvage and acetogenesis during hibernation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. A nonenzymatic effector disruptsProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Specificities of chemosensory receptors in the human gut microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Whitman B SchofieldDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06536, USA.
Maria Zimmermann-KogadeevaDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06536, USA.
Michael ZimmermannDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06536, USA.
Natasha A BarryDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06536, USA.
Andrew L GoodmanDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06536, USA. Electronic address: andrew.goodman@yale.edu.

Funding

Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant PathogensU01AI124275 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI PAMER, ERIC G., XAVIER, JOAO · 2016 to 2020
$8.9M
Causes and consequences of interpersonal microbial variationR35GM118159 · NIGMS · YALE UNIVERSITY · PI Andrew L Goodman · 2016 to 2026
$5.6M
Defining the contribution of interpersonal microbial variation to drug metabolismDP2GM105456 · NIGMS · YALE UNIVERSITY · PI GOODMAN, ANDREW L · 2012 to 2017
$3.0M
Molecular recognition of vitamin B12 and related compounds in human gut microbialR01GM103574 · NIGMS · YALE UNIVERSITY · PI GOODMAN, ANDREW L · 2013 to 2016
$1.2M
NIAID NIH HHS U01 AI124275NIGMS NIH HHS DP2 GM105456NIGMS NIH HHS R01 GM103574NIGMS NIH HHS R35 GM118159Wellcome Trust
6 · The paper itself

Abstract

In the mammalian gut, bacteria compete for resources to maintain their populations, but the factors determining their success are poorly understood. We report that the human gut bacterium Bacteroides thetaiotaomicron relies on the stringent response, an intracellular signaling pathway that allocates resources away from growth, to survive carbon starvation and persist in the gut. Genome-scale transcriptomics,

Indexed as

AnimalsBacteroides thetaiotaomicronCarbonCitric Acid CycleGastrointestinal TractGuanosine PentaphosphateHumansKetoglutaric AcidsMetabolomicsMiceSpecific Pathogen-Free OrganismsSuccinic AcidTranscriptomeCarbonGuanosine PentaphosphateKetoglutaric AcidsSuccinic AcidBacteroidescarbon starvationcommensalmetabolomicsmicrobiome(p)ppGppstringent responsetranscriptomics

Identifiers

PMID30008292
PMCPMC6086485

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.