Evidence map›Paper›PMID 30008113›Full record

ArticleJournal of molecular modeling2018

Characterization of the interactions between coumarin-derivatives and acetylcholinesterase: Examination by NMR and docking simulations.

Nazish U Tanoli, Sheraz A K Tanoli, Antonio G Ferreira, Mazhar Mehmood, Sana Gul, Julia L Monteiro, Lucas C C Vieira, Tiago Venâncio, Arlene G Correa, Zaheer Ul-Haq

Abstract read
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In one paragraph

Article in Journal of molecular modeling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nazish U TanoliDepartment of Metallurgy and Materials Engneering, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Lehtrar Road, Nilore, Islamabad, 45650, Pakistan. zareshnazi@gmail.com.
Sheraz A K TanoliLaboratory of Nuclear Magnetic Resonance, Federal University of São Carlos, Rodovia Washington Luiz, Km 235, São Carlos, SP, 13565-905, Brazil. nmrdoctor@gmail.com.
Antonio G FerreiraLaboratory of Nuclear Magnetic Resonance, Federal University of São Carlos, Rodovia Washington Luiz, Km 235, São Carlos, SP, 13565-905, Brazil.
Mazhar MehmoodDepartment of Metallurgy and Materials Engneering, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Lehtrar Road, Nilore, Islamabad, 45650, Pakistan.
Sana GulDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemicals and Biological Sciences, University of Karachi, Karachi, 75210, Pakistan.
Julia L MonteiroLaboratory of Synthesis of Natural Products, Department of Chemistry, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil.
Lucas C C VieiraLaboratory of Synthesis of Natural Products, Department of Chemistry, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil.
Tiago VenâncioLaboratory of Nuclear Magnetic Resonance, Federal University of São Carlos, Rodovia Washington Luiz, Km 235, São Carlos, SP, 13565-905, Brazil.
Arlene G CorreaLaboratory of Synthesis of Natural Products, Department of Chemistry, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil.
Zaheer Ul-HaqDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemicals and Biological Sciences, University of Karachi, Karachi, 75210, Pakistan.
Universidade Federal de São Carlos · BRPakistan Institute of Engineering and Applied Sciences · PKUniversity of Karachi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is one of the most common forms of dementia and a significant threat to the elderly populations, especially in the Western world. The rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (AChE) at synapses causes the loss of cognitive response that becomes the real cause of AD. Therefore, inhibition of AChE is the most fundamental therapy among currently available treatments for AD. In this context, we designed and performed molecular recognitions studies of coumarin-based inhibitors towards AChE. STD NMR and Tr-NOESY applications were utilized to evaluate the binding epitope, the dissociation constant (K

Indexed as

AcetylcholinesteraseAnimalsBinding SitesCholinesterase InhibitorsCoumarinsCrystallography, X-RayElectrophorusGPI-Linked ProteinsHumansMagnetic Resonance SpectroscopyMolecular Docking SimulationNootropic AgentsProtein BindingProtein Interaction Domains and MotifsProtein Structure, SecondaryTacrineAcetylcholinesteraseACHE protein, humanCholinesterase InhibitorsCoumarinsGPI-Linked ProteinsNootropic AgentsTacrineAcetylcholinesteraseAlzheimer’s diseaseInhibitors-proteinRecognition studySTD-NMRTr-NOESY

Identifiers

PMID30008113
OpenAlexW2884957169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.