ArticleHuman genetics2018
A genome scan for genes underlying adult body size differences between Central African hunter-gatherers and farmers.
Article in Human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Is there a skeletal age index that can predict accurate curve progression in adolescent idiopathic scoliosis? A systematic review.Pediatric radiology · 2024Pooled it
- Reproductive seasonality in the Baka Pygmies, environmental factors and climatic changes.PloS one · 2022Article
- Morphological variation of the deciduous second molars in the Baka Pygmies.Scientific reports · 2021Article
- The same growth pattern from puberty suggests that modern human diversity results from changes during pre-pubertal development.Scientific reports · 2021Article
- Identification of novel genetic variants associated with short stature in a Baka Pygmies population.Human genetics · 2020Article
- Complex Phenotypes: Mechanisms Underlying Variation in Human Stature.Current osteoporosis reports · 2019Review
- Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Short Stature: Understanding the Stature of Ethnicity in Height Determination.Indian journal of endocrinology and metabolismReview
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
The evolutionary and biological bases of the Central African "pygmy" phenotype, a characteristic of rainforest hunter-gatherers defined by reduced body size compared with neighboring farmers, remain largely unknown. Here, we perform a joint investigation in Central African hunter-gatherers and farmers of adult standing height, sitting height, leg length, and body mass index (BMI), considering 358 hunter-gatherers and 169 farmers with genotypes for 153,798 SNPs. In addition to reduced standing heights, hunter-gatherers have shorter sitting heights and leg lengths and higher sitting/standing height ratios than farmers and lower BMI for males. Standing height, sitting height, and leg length are strongly correlated with inferred levels of farmer genetic ancestry, whereas BMI is only weakly correlated, perhaps reflecting greater contributions of non-genetic factors to body weight than to height. Single- and multi-marker association tests identify one region and eight genes associated with hunter-gatherer/farmer status, and 24 genes associated with the height-related traits. Many of these genes have putative functions consistent with roles in determining their associated traits and the pygmy phenotype, and they include three associated with standing height in non-Africans (PRKG1, DSCAM, MAGI2). We find evidence that European height-associated SNPs or variants in linkage disequilibrium with them contribute to standing- and sitting-height determination in Central Africans, but not to the differential status of hunter-gatherers and farmers. These findings provide new insights into the biological basis of the pygmy phenotype, and they highlight the potential of cross-population studies for exploring the genetic basis of phenotypes that vary naturally across populations.
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