ArticleDiabetologia2018
Associations of maternal type 1 diabetes with childhood adiposity and metabolic health in the offspring: a prospective cohort study.
Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Measuring Muscle Post-Exercise Oxygen Consumption in Individuals with a Family History of Diabetes.Journal of functional morphology and kinesiology · 2026Article
- Gestational Diabetes Mellitus: The Impact of Body Mass Index on Clinical Outcomes.Metabolic syndrome and related disorders · 2025Article
- Timing and Variability of Maternal Hyperglycemia in Insulin-Dependent Diabetes, Long-Term Effects on Offspring Obesity-The TEAM Study.Pregnancy (Hoboken, N.J.) · 2025Article
- The emergence of obesity in type 1 diabetes.International journal of obesity (2005) · 2024Review
- Overweight or obesity in children born after assisted reproductive technologies in Denmark: A population-based cohort study.PLoS medicine · 2023Article
- An unwelcome inheritance: childhood obesity after diabetes in pregnancy.Diabetologia · 2023Review
- Maternal-fetal outcomes of pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion or multiple daily injections during pregnancy - A Brazilian health care referral center cohort study.Archives of endocrinology and metabolism · 2023Article
- Higher pulse wave velocity in young adult offspring of mothers with type 1 diabetes: a case-control study.Cardiovascular diabetology · 2022Article
- Glycaemic control and novel technology management strategies in pregestational diabetes mellitus.Frontiers in endocrinology · 2022Review
- Review
- Type 1 Diabetes Mellitus and the First Trimester Placenta: Hyperglycemia-Induced Effects on Trophoblast Proliferation, Cell Cycle Regulators, and Invasion.International journal of molecular sciences · 2021Article
- Associations between insulin resistance and adverse pregnancy outcomes in women with gestational diabetes mellitus: a retrospective study.BMC pregnancy and childbirth · 2021Article
- The long-term metabolic and neurocognitive risks in offspring of women with type 1 diabetes mellitus.Acta diabetologica · 2021Review
- Skin Autofluorescence in Young Adult Offspring of Women with Type 1 Diabetes: A Cross-Sectional Case-Control Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Vascular Endothelial Function Assessed by Flow-Mediated Vasodilatation in Young Adults Born Very Preterm or With Extremely Low Birthweight: A Regional Cohort Study.Frontiers in pediatrics · 2021Article
- Longitudinal relationship of amino acids and indole metabolites with long-term body mass index and cardiometabolic risk markers in young individuals.Scientific reports · 2020Article
- Review
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11 authors at 4 institutions in 1 country.
Funding
Abstract
aims/hypothesisExposure to an intrauterine hyperglycaemic environment has been suggested to increase the offspring's later risk for being overweight or having metabolic abnormalities, but conclusive evidence for pregnancies affected by maternal type 1 diabetes is still lacking. This study aims to analyse the relationship between maternal type 1 diabetes and the offspring's metabolic health and investigate whether birthweight and/or changes in the offspring's metabolome are in the potential pathway.
methodsWe analysed data from 610 and 2169 offspring having a first-degree relative with type 1 diabetes from the TEENDIAB and BABYDIAB/BABYDIET cohorts, respectively. Anthropometric and metabolic outcomes, assessed longitudinally at 0.3-18 years of age, were compared between offspring of mothers with type 1 diabetes and offspring of non-diabetic mothers but with fathers or siblings with type 1 diabetes using mixed regression models. Non-targeted metabolomic measurements were carried out in 500 individuals from TEENDIAB and analysed with maternal type 1 diabetes and offspring overweight status.
resultsThe offspring of mothers with type 1 diabetes had a higher BMI SD score (SDS) and an increased risk for being overweight than the offspring of non-diabetic mothers (e.g. OR for overweight status in TEENDIAB 2.40 [95% CI 1.41, 4.06]). Further, waist circumference SDS, fasting levels of glucose, insulin and C-peptide, and insulin resistance and abdominal obesity were significantly increased in the offspring of mothers with type 1 diabetes, even when adjusted for potential confounders and birthweight. Metabolite patterns related to androgenic steroids and branched-chain amino acids were found to be associated with offspring's overweight status, but no significant associations were observed between maternal type 1 diabetes and metabolite concentrations in the offspring. CONCLUSIONS/
interpretationMaternal type 1 diabetes is associated with offspring's overweight status and metabolic health in later life, but this is unlikely to be caused by alterations in the offspring's metabolome.
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