Evidence map›Paper›PMID 30007914›Full record

ArticleMolecular & cellular proteomics : MCP2018

A Novel Differential Ion Mobility Device Expands the Depth of Proteome Coverage and the Sensitivity of Multiplex Proteomic Measurements.

Sibylle Pfammatter, Eric Bonneil, Francis P McManus, Satendra Prasad, Derek J Bailey, Michael Belford, Jean-Jacques Dunyach, Pierre Thibault

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 130 citations in OpenAlex.

  1. Article
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  6. Isobaric Labeling Update in MaxQuant.Journal of proteome research · 2025
    Article
  7. Enhanced Sample Multiplexing-Based Targeted Proteomics with Intelligent Data Acquisition.Journal of the American Society for Mass Spectrometry · 2024
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sibylle PfammatterFrom the ‡Institute for Research in Immunology and Cancer, H3T 1J4, Québec, Canada.
Eric BonneilFrom the ‡Institute for Research in Immunology and Cancer, H3T 1J4, Québec, Canada.
Francis P McManusFrom the ‡Institute for Research in Immunology and Cancer, H3T 1J4, Québec, Canada.
Satendra Prasad¶Thermo Fisher Scientific, San Jose, California 95134, United States.
Derek J Bailey¶Thermo Fisher Scientific, San Jose, California 95134, United States.
Michael Belford¶Thermo Fisher Scientific, San Jose, California 95134, United States.
Jean-Jacques Dunyach¶Thermo Fisher Scientific, San Jose, California 95134, United States.
Pierre ThibaultFrom the ‡Institute for Research in Immunology and Cancer, H3T 1J4, Québec, Canada; pierre.thibault@umontreal.ca.ORCID 0000-0001-5993-0331
Institute for Research in Immunology and Cancer · CAThermo Fisher Scientific (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The depth of proteomic analyses is often limited by the overwhelming proportion of confounding background ions that compromise the identification and quantification of low abundance peptides. To alleviate these limitations, we present a new high field asymmetric waveform ion mobility spectrometry (FAIMS) interface that can be coupled to the Orbitrap Tribrid mass spectrometers. The interface provides several advantages over previous generations of FAIMS devices, including ease of operation, robustness, and high ion transmission. Replicate LC-FAIMS-MS/MS analyses (

Indexed as

Chromatography, LiquidHeat-Shock ResponseHEK293 CellsHumansIon Mobility SpectrometryIsotope LabelingProtein StabilityProteomeProteomicsReproducibility of ResultsTandem Mass SpectrometryProteomeHeat shockIon mobilityisobaric peptide labelingMass SpectrometryProtein IdentificationProtein TurnoverProteostasisQuantificationTandem Mass Spectrometrytandem mass tag

Identifiers

PMID30007914
PMCPMC6166672
OpenAlexW2883984615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.