Evidence map›Paper›PMID 30007888›Full record

ArticleRedox biology2018

Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells.

Chiang-Wen Lee, Cheng-Hsun Wu, Yao-Chang Chiang, Yuh-Lien Chen, Kuo-Ting Chang, Chu-Chun Chuang, I-Ta Lee

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Heme Causes Pain in Sickle MiceAntioxidants & redox signaling · 2021
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Surfactin fromJournal of Cancer · 2020
    Article
  12. Mechanisms of Blood-Brain Barrier Disruption in Herpes Simplex Encephalitis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Chiang-Wen LeeDivision of Basic Medical Sciences, Department of Nursing and Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC; Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC; Department of Rehabilitation, Chang Gung Memorial Hospital, Chia-Yi, Taiwan, ROC.
Cheng-Hsun WuSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, ROC.
Yao-Chang ChiangDivision of Basic Medical Sciences, Department of Nursing and Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi, Taiwan, ROC; Center for Drug Abuse and Addiction, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC.
Yuh-Lien ChenDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Kuo-Ting ChangTranslational Medicine Center, Taoyuan General Hospital, Ministry of Healthy and Welfare, Taoyuan, Taiwan, ROC.
Chu-Chun ChuangDepartment of Physical Therapy, China Medical University, Taichung, Taiwan, ROC.
I-Ta LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC; Department of Nursing, College of Nursing, Hungkuang University, Taichung, Taiwan, ROC. Electronic address: itl700128@gmail.com.
Chang Gung University of Science and Technology · TWChina Medical University · TWNational Taiwan University · TWTaichung Veterans General Hospital · TWTao Yuan General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudomonas aeruginosa (P. aeruginosa) infection in the lung is common in patients with cystic fibrosis (CF). Intercellular adhesion molecule-1 (ICAM-1) is known to play a key role in lung inflammation. Acute inflammation and its timely resolution are important to ensure bacterial clearance and limit tissue damage. Carbon monoxide (CO) has been shown to exert anti-inflammatory effects in various tissues and organ systems. Here, we explored the protective effects and mechanisms of carbon monoxide releasing molecule-2 (CORM-2) on P. aeruginosa-induced inflammatory responses in human pulmonary alveolar epithelial cells (HPAEpiCs). We showed that P. aeruginosa induced prostaglandin E

Indexed as

Alveolar Epithelial CellsAnimalsAnti-Inflammatory AgentsCell AdhesionCell LineHumansInflammationIntercellular Adhesion Molecule-1Interleukin-6MaleMice, Inbred ICROrganometallic CompoundsPseudomonas aeruginosaPseudomonas InfectionsReactive Oxygen SpeciesAnti-Inflammatory AgentsIntercellular Adhesion Molecule-1Interleukin-6Organometallic CompoundsReactive Oxygen Speciestricarbonyldichlororuthenium (II) dimerCarbon monoxideIntercellular adhesion molecule-1Lung inflammationNADPH oxidasePseudomonas aeruginosa

Identifiers

PMID30007888
PMCPMC6039312
OpenAlexW2810585146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.