Evidence map›Paper›PMID 30007778›Full record

ReviewBest practice & research. Clinical obstetrics & gynaecology2018

Genetic studies of gestational duration and preterm birth.

Ge Zhang, Amit Srivastava, Jonas Bacelis, Julius Juodakis, Bo Jacobsson, Louis J Muglia

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Best practice & research. Clinical obstetrics & gynaecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Maternal-fetal conflict and the timing of birth.Evolution, medicine, and public health · 2025
    Review
  5. Review
  6. Article
  7. A Scoping Review of Preterm Birth Risk Factors.American journal of perinatology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Past Traumatic Life Events, Postpartum PTSD, and the Role of Labor Support.International journal of environmental research and public health · 2023
    Article
  12. Article
  13. Article
  14. Genetics, epigenetics, and transcriptomics of preterm birth.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Recurrent preterm birth risk assessment for two delivery subtypes: A multivariable analysis.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ge ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, USA; The Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, USA; March of Dimes Prematurity Research Center Ohio Collaborative, USA; Department of Pediatrics, University of Cincinnati College of Medicine, USA. Electronic address: ge.zhang@cchmc.org.
Amit SrivastavaDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, USA; The Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, USA; March of Dimes Prematurity Research Center Ohio Collaborative, USA; Department of Pediatrics, University of Cincinnati College of Medicine, USA.
Jonas BacelisDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra (East), Gothenburg, Sweden.
Julius JuodakisDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bo JacobssonDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Genetics and Bioinformatics, Area of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.
Louis J MugliaDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, USA; The Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, USA; March of Dimes Prematurity Research Center Ohio Collaborative, USA; Department of Pediatrics, University of Cincinnati College of Medicine, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fine control of birth timing is important to human survival and evolution. A key challenge in studying the mechanisms underlying the regulation of human birth timing is that human parturition is a unique to human event - animal models provide only limited information. The duration of gestation or the risk of preterm birth is a complex human trait under genetic control from both maternal and fetal genomes. Genomic discoveries through genome-wide association (GWA) studies would implicate relevant genes and pathways. Similar to other complex human traits, gestational duration is likely to be influenced by numerous genetic variants of small effect size. The detection of these small-effect genetic variants requires very large sample sizes. In addition, several practical and analytical challenges, in particular the involvement of both maternal and fetal genomes, further complicate the genetic studies of gestational duration and other pregnancy phenotypes. Despite these challenges, large-scale GWA studies have already identified several genomic loci associated with gestational duration or the risk of preterm birth. These genomic discoveries have revealed novel insights about the biology of human birth timing. Expanding genomic discoveries in larger datasets by more refined analytical approaches, together with the functional analysis of the identified genomic loci, will collectively elucidate the biological processes underlying the control of human birth timing.

Indexed as

Genetic VariationGestational AgeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansParturitionPhenotypePregnancyPremature BirthComplex human traitGenome-wide associationGestational durationPreterm birth

Identifiers

PMID30007778
PMCPMC6290110

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.