ArticleCell2018
The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis.
Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Soybean-Derived Soluble Fiber Enhances Antimicrobial Proteins in the Mouse Small Intestine via a Tuft Cell-Group 2 Innate Lymphoid Cell Axis.Journal of agricultural and food chemistry · 2026Article
- The signature of the small intestinal epithelial and immune cells in health and diseases.Chinese medical journal · 2025Review
- Spatial mapping of innate lymphoid cells in human lymphoid tissues and lymphoma at single-cell resolution.Nature communications · 2025Article
- The role of the tuft cell-interleukin-25 axis in the pathogenesis of inflammatory bowel disease.Frontiers in immunology · 2025Review
- The supernatant ofFrontiers in microbiology · 2025Article
- Atopic dermatitis and food allergy: More than sensitization.Mucosal immunology · 2024Review
- Colonic Tuft Cells: The Less-Recognized Therapeutic Targets in Inflammatory Bowel Disease and Colorectal Cancer.International journal of molecular sciences · 2024Review
- A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development.Nature communications · 2023Article
- Review
- Modulation by luminal factors on the functions and migration of intestinal innate immunity.Frontiers in immunology · 2023Review
- The critical roles and therapeutic implications of tuft cells in cancer.Frontiers in pharmacology · 2022Review
- Plasticity of Intestinal Epithelium: Stem Cell Niches and Regulatory Signals.International journal of molecular sciences · 2020Review
- Targeting the aryl hydrocarbon receptor in stem cells to improve the use of food as medicine.Current stem cell reports · 2020Article
- Combination of TLR agonist and miR146a mimics attenuates ovalbumin-induced asthma.Molecular medicine (Cambridge, Mass.) · 2020Article
- Metabolism at the centre of the host-microbe relationship.Clinical and experimental immunology · 2019Review
- Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome.Signal transduction and targeted therapyReview
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.
Indexed as
Identifiers
30007413What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.