Evidence map›Paper›PMID 30007041›Full record

ArticleBritish journal of clinical pharmacology2018

Development of a standardized chart review method to identify drug-related hospital admissions in older people.

Stefanie Thevelin, Anne Spinewine, Jean-Baptiste Beuscart, Benoit Boland, Sophie Marien, Fanny Vaillant, Ingeborg Wilting, Ariel Vondeling, Carmen Floriani, Claudio Schneider and 5 more

Abstract readValidation Study
In one paragraph

Article in British journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Drug-Related Hospital AdmissionsFrontiers in pharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stefanie ThevelinClinical Pharmacy Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.ORCID 0000-0003-4864-0691
Anne SpinewineClinical Pharmacy Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Jean-Baptiste BeuscartClinical Pharmacy Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.ORCID 0000-0002-0734-8371
Benoit BolandDepartment of Geriatric Medicine, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
Sophie MarienClinical Pharmacy Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Fanny VaillantPharmacy Department, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
Ingeborg WiltingDepartment of Clinical Pharmacy, Division Laboratory and Pharmacy, University Medical Centre Utrecht, Utrecht, the Netherlands.
Ariel VondelingDepartment of Geriatric Medicine and Expertise Centre Pharmacotherapy in Older Persons (EPHOR), University Medical Centre Utrecht, Utrecht, the Netherlands.
Carmen FlorianiDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Claudio SchneiderDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Jacques DonzéDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Nicolas RodondiDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Shane CullinanPharmaceutical Care Research Group, School of Pharmacy, Cavanagh Pharmacy Building, University College Cork, College Road, Cork, Ireland.
Denis O'MahonyDepartment of Geriatric Medicine, Cork University Hospital and Department of Medicine, University College Cork, Cork, Ireland.
Olivia DalleurClinical Pharmacy Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe aimed to develop a standardized chart review method to identify drug-related hospital admissions (DRA) in older people caused by non-preventable adverse drug reactions and preventable medication errors including overuse, underuse and misuse of medications: the DRA adjudication guide.

methodsThe DRA adjudication guide was developed based on design and test iterations with international and multidisciplinary input in four subsequent steps: literature review; evaluation of content validity using a Delphi consensus technique; a pilot test; and a reliability study.

resultsThe DRA adjudication guide provides definitions, examples and step-by-step instructions to measure DRA. A three-step standardized chart review method was elaborated including: (i) data abstraction; (ii) explicit screening with a newly developed trigger tool for DRA in older people; and (iii) consensus adjudication for causality by a pharmacist and a physician using the World Health Organization-Uppsala Monitoring Centre and Hallas criteria. A 15-member international Delphi panel reached consensus agreement on 26 triggers for DRA in older people. The DRA adjudication guide showed good feasibility of use and achieved moderate inter-rater reliability for the evaluation of 16 cases by four European adjudication pairs (71% agreement, κ = 0.41). Disagreements arose mainly for cases with potential underuse.

conclusionsThe DRA adjudication guide is the first standardized chart review method to identify DRA in older persons. Content validity, feasibility of use and inter-rater reliability were found to be satisfactory. The method can be used as an outcome measure for interventions targeted at improving quality and safety of medication use in older people.

Indexed as

AgedDelphi TechniqueDrug-Related Side Effects and Adverse ReactionsFeasibility StudiesFemaleHospitalizationHumansMaleMedication ErrorsObserver VariationPilot ProjectsReproducibility of Resultsadverse drug reactionselderlymedication errorsmedication safetypatient safety

Identifiers

PMID30007041
PMCPMC6177723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.