ArticleJournal of clinical hypertension (Greenwich, Conn.)2018
Arterial damage and cognitive decline in chronic kidney disease patients.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Arterial Stiffness and Cognition Among Adults: A Systematic Review and Meta-Analysis of Observational and Longitudinal Studies.Journal of the American Heart Association · 2020Pooled it
- The Usefulness of Falls Efficacy Scale-International in Predicting Falls in Chronic Kidney Disease Patients.Journal of clinical medicine · 2026Article
- Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index.The Journal of clinical endocrinology and metabolism · 2026Article
- Structural brain changes, cerebral oxygenation, and cognitive function in hemodialysis patients: a cross-sectional study.Frontiers in medicine · 2026Article
- Cf-PWV but not cr-PWV or cd-PWV is associated with cardiovascular mortality in patients with chronic kidney disease.BMC nephrology · 2025Article
- Motor Coordination Disorders in Patients with Chronic Kidney Disease.Journal of clinical medicine · 2025Article
- Regulation of the blood-brain barrier function by peripheral cues in health and disease.Metabolic brain disease · 2024Review
- The Role of Hypertension in Cognitive Dysfunction.Journal of clinical medicine · 2024Review
- Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2024Article
- Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis.Kidney diseases (Basel, Switzerland) · 2022Review
- Investigation of Possible Correlation Between Retinal Neurovascular Biomarkers and Early Cognitive Impairment in Patients With Chronic Kidney Disease.Translational vision science & technology · 2021Article
- Cognitive and vascular function in older adults with and without CKD.Aging clinical and experimental research · 2021Article
- Pathophysiology and consequences of arterial stiffness in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Review
- Hydrogen Sulfide and Carnosine: Modulation of Oxidative Stress and Inflammation in Kidney and Brain Axis.Antioxidants (Basel, Switzerland) · 2020Review
- Article
- A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis.Disease markers · 2019Article
- Arterial damage and cognitive impairment in patients with chronic kidney disease.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Arterial damage and cognitive decline in chronic kidney disease patients.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In the general population aortic stiffening, assessed by carotid femoral pulse wave velocity (cf-PWV), is associated with cognitive dysfunction (CO/DY). Data in chronic kidney disease (CKD) are limited. This study tests the hypothesis that large artery stiffness and microvascular damage in CKD patients are related to the damage of brain microcirculation reflected by impaired cognitive function. A cross-sectional study enrolled 151 patients (mean age 58.4 years; 64.5% males; 44 patients with CKD stage 1; 47 with stage 2; 25 with stage 3; and 35 with stage 4). Cognitive impairment, assessed by the Mini Mental State Examination (MMSE), the Clock - drawing test (Clock-test), and the Instrumental Activity of Daily Living (IADL), was considered as primary outcome. We measured systolic and pulse pressures at the brachial and aortic sites and cf-PWV. Our patients revealed a significant linear deterioration in all the domains of cognitive function according to CKD stages. High values of cf-PWV (P = 0.029) and aortic pulse pressure (aPP) (P < 0.026) were independent determinants of cognitive decline assessed by the MMSE. The present trial supports the hypothesis of an interaction between the kidney, large artery damage, central pressure pulsatility, and the injury of brain microcirculation. In clinical practice, cf-PWV and aPP measurements may help to predict cognitive decline. Whether the reduction in aortic stiffness following an aggressive treatment translates into improved cognitive outcomes remains to be determined.
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