ArticleJournal of gastroenterology2019
Hepatocellular carcinoma as a leading cause of cancer-related deaths in Japanese type 2 diabetes mellitus patients.
Article in Journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Link between type 2 diabetes mellitus and hepatocellular carcinoma.World journal of hepatology · 2025Review
- Comparison of kidney and hepatic outcomes among sodium-glucose cotransporter-2 inhibitors: a retrospective study using multiple propensity scores.Journal of pharmaceutical health care and sciences · 2024Article
- Glycemic Control Is Associated with Histological Findings of Nonalcoholic Fatty Liver Disease.Diabetes & metabolism journal · 2024Observational
- Risk Stratification of Advanced Fibrosis in Patients With Human Immunodeficiency Virus and Hepatic Steatosis Using the Fibrosis-4, Nonalcoholic Fatty Liver Disease Fibrosis, and BARD Scores.Open forum infectious diseases · 2024Article
- Risk Stratification of Advanced Fibrosis in HIV Patients With Hepatic Steatosis Using the NAFLD Fibrosis and BARD Scores.medRxiv : the preprint server for health sciences · 2023Article
- Causes of death in Japanese people with type 2 diabetes and factors associated with all-cause mortality from a large registry in Japan: the Japan Diabetes Complication and its prevention prospective (JDCP) study-9.Diabetology international · 2023Article
- Combined evaluation of Fibrosis-4 index and fatty liver for stratifying the risk for diabetes mellitus.Journal of diabetes investigation · 2022Article
- Fatty liver with metabolic disorder, such as metabolic dysfunction-associated fatty liver disease, indicates high risk for developing diabetes mellitus.Journal of diabetes investigation · 2022Article
- Nonalcoholic fatty liver disease is a risk factor for glucose intolerance onset in men regardless of alanine aminotransferase status.Journal of diabetes investigation · 2021Article
- Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study.BMC gastroenterology · 2021Article
- Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan.Journal of gastroenterology · 2021Article
- Association between Liver Cirrhosis and Diabetes Mellitus: A Review on Hepatic Outcomes.Journal of clinical medicine · 2021Review
- Hepatocellular Carcinoma and Obesity, Type 2 Diabetes Mellitus, Cardiovascular Disease: Causing Factors, Molecular Links, and Treatment Options.Frontiers in endocrinology · 2021Review
- Mechanisms Underlying Hepatocellular Carcinoma Progression in Patients with Type 2 Diabetes.Journal of hepatocellular carcinoma · 2021Review
- Common Drug Pipelines for the Treatment of Diabetic Nephropathy and Hepatopathy: Can We Kill Two Birds with One Stone?International journal of molecular sciences · 2020Review
- Epidemiology: Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan.International journal of molecular sciences · 2020Review
- Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis.International journal of molecular sciences · 2020Review
- VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma.BMC gastroenterology · 2019Article
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Authors and funding
13 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundWe reported a cross-sectional study on causes of liver injury in Japanese type 2 diabetes mellitus (T2D) patients (JG 2013). We assessed overall and cause-specific mortality risk during follow-up of patients enrolled in JG 2013.
methodsThis was a longitudinal, multicenter cohort study. Of the 5642 Japanese T2D patients who visited T2D clinics of nine hospitals in the original study, 3,999 patients were followed up for an average of 4.5 years. Expected deaths in T2D patients were estimated using age-specific mortality rates in the general population (GP) of Japan. Standardized mortality ratios (SMRs) were calculated to compare mortality between T2D patients and GP.
resultsAll-cancer mortality was significantly higher in T2D patients than in the GP [SMR 1.58, 95% confidence interval (CI) 1.33-1.87]. Among malignancies, hepatocellular carcinoma (HCC) conferred the highest mortality risk in T2D patients (SMR 3.57, 95% CI 2.41-5.10). HCC-associated mortality risk in T2D patients remained significantly high (SMR 2.56, 95% CI 1.64-3.97) after adjusting for high positivity rates of hepatitis B surface antigen (1.7%) and anti-hepatitis C virus (5.3%). In T2D patients with platelet counts < 200 × 10
conclusionsHCC-associated mortality risk was the highest among all cancers in Japanese T2D patients. Regular follow-up may be important for T2D patients with platelet counts < 200 × 10
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