ArticleEuropean journal of applied physiology2018
Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits.
Article in European journal of applied physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Effects of Exercise Training on Mitochondrial and Capillary Growth in Human Skeletal Muscle: A Systematic Review and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Why Do Humans Exercise? A Neuro-Evolutionary Framework for Discretionary Physical Effort.Evolutionary anthropology · 2026Review
- Article
- Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy.Developmental medicine and child neurology · 2026Review
- What Is 'Muscle Health'? A Narrative Review and Conceptual Framework.Journal of functional morphology and kinesiology · 2025Review
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Multi-Omics Identification ofBiology · 2025Article
- Physiological Resilience: What Is It and How Might It Be Trained?Scandinavian journal of medicine & science in sports · 2025Review
- Training-Induced Metabolic Adaptations in Skeletal Muscle.Advances in experimental medicine and biology · 2025Review
- Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis.Scientific reports · 2024Article
- Exposome on skeletal muscle system: a mini-review.European journal of applied physiology · 2024Review
- Article
- Muscle fiber phenotype: a culprit of abnormal metabolism and function in skeletal muscle of humans with obesity.American journal of physiology. Endocrinology and metabolism · 2023Review
- Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023Review
- Exercise and Experiments of Nature.Comprehensive Physiology · 2023Article
- Genome-Wide Association Study IdentifiesCells · 2022Article
- Modern physiology vindicates Darwin's dream.Experimental physiology · 2022Review
- Localized Heat Therapy Improves Mitochondrial Respiratory Capacity but Not Fatty Acid Oxidation.International journal of molecular sciences · 2022Article
- Exercise-mediated reinnervation of skeletal muscle in elderly people: An update.European journal of translational myology · 2022Article
- Controversies in TWEAK-Fn14 signaling in skeletal muscle atrophy and regeneration.Cellular and molecular life sciences : CMLS · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
introductionPhysical health and function depend upon both genetic inheritance and environmental factors (e.g., exercise training). PURPOSE: To enhance the understanding of heritability/adaptability, we explored the skeletal muscle health and physiological performance of monozygotic (MZ) twins with > 30 years of chronic endurance training vs. no specific/consistent exercise.
methodsOne pair of male MZ twins (age = 52 years; Trained Twin, TT; Untrained Twin, UT) underwent analyses of: (1) anthropometric characteristics and blood profiles, (2) markers of cardiovascular and pulmonary health, and (3) skeletal muscle size, strength, and power and molecular markers of muscle health.
resultsThis case study represents the most comprehensive physiological comparison of MZ twins with this length and magnitude of differing exercise history. TT exhibited: (1) lower body mass, body fat%, resting heart rate, blood pressure, cholesterol, triglycerides, and plasma glucose, (2) greater relative cycling power, anaerobic endurance, and aerobic capacity (VO
conclusionsSeveral measured differences are the largest reported between MZ twins (TT expressed 55% more MHC I fibers, 12.4 ml/kg/min greater VO
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.