ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2018
The impact of depression on health-related quality of life and wellbeing: identifying important dimensions and assessing their inclusion in multi-attribute utility instruments.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychometric properties of the EQ-5D-5L: a systematic review of the literature.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Pooled it
- Assessing measurement properties of EQ-5D-5L and ICECAP-A in patients with chronic depression in England.Health and quality of life outcomes · 2025Trial
- The Cost-Effectiveness of a Novel Online Social Therapy to Maintain Treatment Effects From First-Episode Psychosis Services: Results From the Horyzons Randomized Controlled Trial.Schizophrenia bulletin · 2024Trial
- Incorporating a Stepped Care Approach Into Internet-Based Cognitive Behavioral Therapy for Depression: Randomized Controlled Trial.JMIR mental health · 2024Trial
- Quality of Life Measurement Tools in Interventions for Anxiety and Depressive Disorders: A Systematic Literature Review in Global Settings.Neuropsychiatric disease and treatment · 2026Review
- Longitudinal bidirectional association between psychosocial function and depression in Chinese patients with clinically remitted depression: a cross-lagged panel model analysis.BMC psychiatry · 2025Article
- Article
- Health-related quality of life and utility values among patients with anxiety and/or depression in a low-income tertiary care setting: a cross-sectional analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Childhood maltreatment and major depressive disorder in well-being: a network analysis of a longitudinal community-based cohort.Psychological medicine · 2023Article
- Responsiveness to change in health status of the EQ-5D in patients treated for depression and anxiety.Health and quality of life outcomes · 2023Observational
- Measuring the relationship between body mass index and depression among Saudi adult population: A nationwide cross-sectional study.PloS one · 2023Article
- Genomic-Analysis-Oriented Drug Repurposing in the Search for Novel Antidepressants.Biomedicines · 2022Article
- Adapting Peer Researcher Facilitated Strategies to Recruit People Receiving Mental Health Services to a Tobacco Treatment Trial.Frontiers in psychiatry · 2022Article
- Associations of Cognitive Complaints and Depressive Symptoms with Health-Related Quality of Life and Perceived Overall Health in Japanese Adult Volunteers.International journal of environmental research and public health · 2021Article
- Health-related quality of life in adults with profound postlingual hearing loss before and after cochlear implantation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Tobacco Use and Health-Related Quality of Life Among Individuals with Depression Who Are Receiving Treatment for HIV in Cape Town, South Africa.International journal of behavioral medicine · 2021Article
- Overlap of Depressive Symptoms with Health-Related Quality-of-Life Measures.PharmacoEconomics · 2021Article
- Empirical Validity of a Generic, Preference-Based Capability Wellbeing Instrument (ICECAP-A) in the Context of Spinal Cord Injury.The patient · 2021Article
- Capability instruments in economic evaluations of health-related interventions: a comparative review of the literature.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeWellbeing measures have been proposed for inclusion in economic evaluation to measure the effect of depression and compensate for shortcomings of existing multi-attribute utility instruments (MAUIs). The aims of this study were to identify dimensions of health-related quality of life (HRQoL) and wellbeing that are most affected by depression and to examine the extent to which these are captured by MAUIs.
methodsData were used from the Multi-Instrument Comparison study. Dimensions of HRQoL (SF-36v2 and AQoL-8D dimensions), capability wellbeing (ICECAP-A), and subjective wellbeing (including PWI, SWLS, and IHS) were identified that distinguished most individuals with depression from a healthy public. The extent to which these dimensions explain the content of five existing MAUIs (15D, AQoL-8D, EQ-5D-5L, HUI-3, and SF-6D) was examined using regression analyses. Additionally, the sensitivity of all MAUIs was also assessed towards depression-specific symptoms measured by DASS-21 and K-10.
resultsThe sample consisted of 917 individuals with self-reported depression and 1760 healthy subjects. Dimensions that distinguished most individuals with depression from the healthy group (effect size > 2) included AQoL-8D coping, AQoL-8D happiness, AQoL-8D self-worth, ICECAP-A, SF-36 mental health, and SF-36 social functioning. The AQoL-8D was most sensitive to the dimensions above as well as towards the depression-specific measures, the K10, DASS-S, and DASS-D.
conclusionsThis study has shown that psychosocial dimensions of HRQoL have the greatest ability to capture the impact of depression when compared with dimensions of capability wellbeing and SWB. Some MAUIs, such as the AQoL-8D, are sensitive to most distinguishing dimensions of HRQoL and wellbeing, which may obviate the need for supplementary wellbeing instruments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.