ArticleNature communications2018
Single-molecule insights into surface-mediated homochirality in hierarchical peptide assembly.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- The effect of lateral π-extension on azulene-based molecules on surface studied by LT-STM.Scientific reports · 2026Article
- Primitive homochiral polyester formation driven by tartaric acid and calcium availability.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Light-regulating chirality of metallacages featuring dithienylethene switches.Chemical science · 2023Article
- Chiral MOFs encapsulated by polymers with poly-metallic coordination as chiral biosensors.Mikrochimica acta · 2023Article
- Design of Peptides that Fold and Self-Assemble on Graphite.Journal of chemical information and modeling · 2022Article
- Breakdown of chiral recognition of amino acids in reduced dimensions.Scientific reports · 2020Article
- Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures.Frontiers in chemistry · 2020Review
- Towards homochiral supramolecular entities from achiral molecules by vortex mixing-accompanied self-assembly.Chemical science · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Homochirality is very important in the formation of advanced biological structures, but the origin and evolution mechanisms of homochiral biological structures in complex hierarchical process is not clear at the single-molecule level. Here we demonstrate the single-molecule investigation of biological homochirality in the hierarchical peptide assembly, regarding symmetry break, chirality amplification, and chirality transmission. We find that homochirality can be triggered by the chirality unbalance of two adsorption configuration monomers. Co-assembly between these two adsorption configuration monomers is very critical for the formation of homochiral assemblies. The site-specific recognition is responsible for the subsequent homochirality amplification and transmission in their hierarchical assembly. These single-molecule insights open up inspired thoughts for understanding biological homochirality and have general implications for designing and fabricating artificial biomimetic hierarchical chiral materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.