ArticleInternational journal of obesity (2005)2019
Metabolically healthy and unhealthy obesity phenotypes and risk of renal stone: a cohort study.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Impact of changes in metabolic health and obesity on incident urolithiasis: A nationwide cohort study.Investigative and clinical urology · 2026Article
- Causal Association Between Body Mass Index and Kidney Stone Disease in Taiwanese: A Mendelian Randomization Study.International journal of medical sciences · 2026Article
- Nephrolithiasis risk factors for obese patients on 24-hour urine collection metabolic evaluation.BJUI compass · 2025Article
- Exploring the pathophysiological link between obesity and kidney stone formation: cost-effective dietary and lifestyle strategies for prevention.Annals of medicine and surgery (2012) · 2025Review
- Diabetes mediates an inverted L-shaped association between cardiometabolic index and kidney stones: a cross-sectional study from NHANES 2007-2020.Frontiers in endocrinology · 2025Article
- Changes in metabolic overweight phenotypes over time and risk of nephrolithiasis: a cohort study.BMC public health · 2024Article
- Analysis of metabolic syndrome in bilateral upper urinary tract stones: A retrospective study of 3905 cases.Heliyon · 2024Article
- Metabolic health status and renal disorders: a cross-sectional study.Scientific reports · 2023Article
- Prognostic value of total body muscle-fat ratio in patients with kidney stone disease: A US population-based study.Heliyon · 2023Article
- Association between metabolically healthy obesity and kidney stones: results from the 2011-2018 National Health and Nutrition Examination Survey.Frontiers in public health · 2023Article
- Metabolically Healthy Obesity and Carotid Plaque among Steelworkers in North China: The Role of Inflammation.Nutrients · 2022Article
- Sex disparities and the risk of urolithiasis: a large cross-sectional study.Annals of medicine · 2022Article
- Association of Metabolically Healthy Obesity and Glomerular Filtration Rate among Male Steelworkers in North China.International journal of environmental research and public health · 2022Article
- Obesity phenotypes related to musculoskeletal disorders; a cross-sectional study from RaNCD cohort.Archives of public health = Archives belges de sante publique · 2022Article
- Relationship between hepatitis C and kidney stone in US females: Results from the National Health and Nutrition Examination Survey in 2007-2018.Frontiers in public health · 2022Article
- Association between body fat distribution and kidney stones: Evidence from a US population.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesAlthough obesity is considered an independent risk factor of nephrolithiasis, little is known about the effect of obesity on nephrolithiasis according to metabolic health status. We investigated the association between body mass index (BMI) category and the incidence of nephrolithiasis in metabolically healthy and unhealthy individuals. SUBJECTS/
methodsThe cohort consisted of 270,190 Korean adults free of nephrolithiasis at baseline, who were followed-up annually or biennially for a median of 4.1 years. Nephrolithiasis were determined based on ultrasonographic findings. Being metabolically healthy was defined as not having any metabolic syndrome component. A parametric Cox model was used to estimate the adjusted hazard ratios (HRs) with 95% confidence intervals (CIs).
resultsDuring 1,415,523.0 person-years of follow-up, 13,450 participants developed nephrolithiasis (incidence rate, 9.5 per 1000 person-years). Obesity was positively associated with an increased risk of incident nephrolithiasis in dose-response manner, but the association was stronger in metabolically healthy individuals. Among metabolically healthy individuals, the multivariable-adjusted HRs (95% CIs) for incident nephrolithiasis comparing BMIs 23-24.9, 25-29.9, and ≥30 with a BMI of 18.5-22.9 kg/m
conclusionsObesity was associated with a higher incidence of nephrolithiasis in both metabolically healthy and unhealthy individuals, indicating obesity per se as an independent risk factor for nephrolithiasis.
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