ArticleScientific reports2018
Sub-nanoliter, real-time flow monitoring in microfluidic chips using a portable device and smartphone.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Portable microfluidic titration using a cross-shaped microfluidic device and smartphone camera for on-site quantitative analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Microfluidic Sensors for Micropollutant Detection in Environmental Matrices: Recent Advances and Prospects.Biosensors · 2025Review
- A passive flow microreactor for urine creatinine test.Microsystems & nanoengineering · 2025Article
- A film-lever actuated switch technology for multifunctional, on-demand, and robust manipulation of liquids.Nature communications · 2022Article
- Capacitive Sensor and Alternating Drive Mixing for Microfluidic Applications Using Micro Diaphragm Pumps.Sensors (Basel, Switzerland) · 2022Article
- Multi-frequency impedance sensing for detection and sizing of DNA fragments.Scientific reports · 2021Article
- Toward improvedAPL bioengineering · 2021Article
- Skin-interfaced soft microfluidic systems with modular and reusable electronics forLab on a chip · 2020Article
- A Noninvasive Wearable Device for Real-Time Monitoring of Secretion Sweat Pressure by Digital Display.iScience · 2020Article
- Open-Channel Capillary Trees and Capillary Pumping.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- PRADA: Portable Reusable Accurate Diagnostics with nanostar Antennas for multiplexed biomarker screening.Bioengineering & translational medicine · 2020Article
- Study on Functionality and Surface Modification of a Stair-Step Liquid-Triggered Valve for On-Chip Flow Control.Micromachines · 2020Article
- Electro-actuated valves and self-vented channels enable programmable flow control and monitoring in capillary-driven microfluidics.Science advances · 2020Article
- Programmable hydraulic resistor for microfluidic chips using electrogate arrays.Scientific reports · 2019Article
- A Capillary-Evaporation Micropump for Real-Time Sweat Rate Monitoring with an Electrochemical Sensor.Micromachines · 2019Article
- Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making.ACS sensors · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ever-increasing need for portable, easy-to-use, cost-effective, and connected point-of-care diagnostics (POCD) has been one of the main drivers of recent research on lab-on-a-chip (LoC) devices. A majority of these devices use microfluidics to manipulate precisely samples and reagents for bioanalysis. However, filling microfluidic devices with liquid can be prone to failure. For this reason, we have implemented a simple, yet efficient method for monitoring liquid displacement in microfluidic chips using capacitive sensing and a compact (75 mm × 30 mm × 10 mm), low-cost ($60), and battery-powered (10-hour autonomy) device communicating with a smartphone. We demonstrated the concept using a capillary-driven microfluidic chip comprising two equivalent flow paths, each with a total volume of 420 nL. Capacitance measurements from a pair of electrodes patterned longitudinally along the flow paths yielded 17 pL resolution in monitoring liquid displacement at a sampling rate of 1 data/s (~1 nL/min resolution in the flow rate). We characterized the system using human serum, biological buffers, and water, and implemented an algorithm to provide real-time information on flow conditions occurring in a microfluidic chip and interactive guidance to the user.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.