ArticleScientific reports2018
Relationships of Age and Sex with Cytokine Content and Distribution in Human Platelet Fibrin Gels.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Macroscopic handling stability of platelet-rich fibrin under short-term temperature variations: a prospective experimental study.Oral and maxillofacial surgery · 2026Article
- Effect of tube cooling on the osteogenic activity of concentrated platelet-rich fibrin in human periodontal ligament cells.Biomaterial investigations in dentistry · 2026Article
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- Advanced platelet rich fibrin demonstrates improved osteogenic induction potential in human periodontal ligament cells, growth factor production and mechanical properties as compared to leukocyte and platelet fibrin and injectable platelet rich fibrin.Oral and maxillofacial surgery · 2024Article
- Understanding Solid-Based Platelet-Rich Fibrin Matrices in Oral and Maxillofacial Surgery: An Integrative Review of the Critical Protocol Factors and Their Influence on the Final Product.Medicina (Kaunas, Lithuania) · 2023Review
- Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs.International journal of molecular sciences · 2023Review
- Peripheral mononuclear cells composition in platelet-rich fibrin in canines with chronic conditions.Scientific reports · 2022Article
- The effect of resting and compression time post-centrifugation on the characteristics of platelet rich fibrin (PRF) membranes.Clinical oral investigations · 2022Article
- Platelets in aging and cancer-"double-edged sword".Cancer metastasis reviews · 2020Review
- Preclinical studies of non-stick thin film metallic glass-coated syringe needles.Scientific reports · 2020Article
- Factors associated with positive outcomes of platelet-rich plasma therapy in Achilles tendinopathy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Article
- Cytokine and Growth Factor Delivery from Implanted Platelet-Rich Fibrin Enhances Rabbit Achilles Tendon Healing.International journal of molecular sciences · 2020Article
- The impact of gender and peripheral blood parameters on the characteristics of L-PRF membranes.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to determine relationships between age and sex with cytokine content and distribution in human platelet-rich fibrin (PRF) gel. Rabbit PRF was harvested from whole blood (n = 6). Human PRF was collected from 36 healthy volunteers (1:1 men:women) without systemic diseases and not current undergoing medical treatment. Histological analysis and optical microscopy were used to assess the three-dimensional structure of the PRF network. Enzyme-linked immunosorbent assays, quantification of adenosine triphosphate, and bioluminescence imaging of PRF sections were used to assess cytokine and entrapped platelet distribution. Three-dimensional structures of fibrin networks revealed concentration gradients of the platelet-derived growth factor beta beta homodimer and the transforming growth factor-beta 1. Histological analysis of PRF sections (from the red blood cell end to the plasma end of a clot) showed a gradual increase in average porosity, most prominently in PRF clots from young and middle-aged men and women, and a decrease in compactness along the longitudinal axis of the PRF gel. The end of the PRF gel closest to the red blood cell layer is the essence of the PRF clot, and the ability to generate platelets depends on sex and age in humans.
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