Evidence map›Paper›PMID 30006552›Full record

ArticleScientific reports2018

Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons.

Joseph D Zak, Julien Grimaud, Rong-Chang Li, Chih-Chun Lin, Venkatesh N Murthy

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. The CaThe Journal of physiology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Longitudinal imaging of individual olfactory sensory neuronsFrontiers in cellular neuroscience · 2022
    Article
  10. Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent ClFrontiers in cellular neuroscience · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joseph D ZakDepartment of Molecular and Cellular Biology & Center for Brain Science, Harvard University, 16 Divinity Ave, Cambridge, MA, 02138, USA.
Julien GrimaudDepartment of Molecular and Cellular Biology & Center for Brain Science, Harvard University, 16 Divinity Ave, Cambridge, MA, 02138, USA.ORCID 0000-0001-8123-1131
Rong-Chang LiJohns Hopkins University School of Medicine, Preclinical Teaching Building Room 905A, 725 North Wolfe Street, MD, 21205, Baltimore, USA.
Chih-Chun LinJohns Hopkins University School of Medicine, Preclinical Teaching Building Room 905A, 725 North Wolfe Street, MD, 21205, Baltimore, USA.ORCID 0000-0002-7602-8590
Venkatesh N MurthyDepartment of Molecular and Cellular Biology & Center for Brain Science, Harvard University, 16 Divinity Ave, Cambridge, MA, 02138, USA. vnmurthy@fas.harvard.edu.ORCID 0000-0003-2443-4252
Harvard University · USJohns Hopkins University · US

Funding

Cyclic AMP- and Ca2+-Signaling in Sensory Transduction by Olfactory Receptor NeuronsR01DC014941 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI KING-WAI YAU · 2016 to 2026
$3.8M
Neuromodulation of sensory processing by the serotonin systemR01DC014453 · NIDCD · HARVARD UNIVERSITY · PI MURTHY, VENKATESH N · 2015 to 2019
$1.8M
Information Coding in Individual Olfactory Sensory AxonsF32DC015938 · NIDCD · HARVARD UNIVERSITY · PI ZAK, JOSEPH DONALD · 2017 to 2019
$165k
NIDCD NIH HHS F32 DC015938NIDCD NIH HHS R01 DC014453NIDCD NIH HHS R01 DC014941U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01 DC14454
6 · The paper itself

Abstract

The calcium-activated chloride channel anoctamin-2 (Ano2) is thought to amplify transduction currents in olfactory receptor neurons (ORNs), a hypothesis supported by previous studies in dissociated neurons from Ano2

Indexed as

AnimalsAnoctaminsEvoked Potentials, SomatosensoryFeedback, PhysiologicalIntravital MicroscopyMiceMice, Inbred C57BLMice, KnockoutMicroscopy, FluorescenceOdorantsOlfactory BulbOlfactory Receptor NeuronsSignal TransductionSmellANO2 protein, mouseAnoctamins

Identifiers

PMID30006552
PMCPMC6045664
OpenAlexW2949102081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.